Helicobacter pylori infection is not associated with failure to thrive: a case–control study
Nan-Chang Chiu,1,2,* Chien-Yu Lin,3,* Hsin Chi,1 Chun-Yan Yeung,1,2 Wei-Hsin Ting,1 Wai-Tao Chan,1 Chuen-Bin Jiang,1 Sung-Tse Li,3,4 Chao-Hsu Lin,3 Hung-Chang Lee1,2 1Department of Pediatrics, MacKay Children’s Hospital, 2Department of Medicine, MacKay Junior College of Medicine, Nursing...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-02-01
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| Series: | Therapeutics and Clinical Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/helicobacter-pylori-infection-is-not-associated-with-failure-to-thrive-peer-reviewed-article-TCRM |
| _version_ | 1819001178270203904 |
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| author | Chiu NC Lin CY Chi H Yeung CY Ting WH Chan WT Jiang CB Li ST Lin CH Lee HC |
| author_facet | Chiu NC Lin CY Chi H Yeung CY Ting WH Chan WT Jiang CB Li ST Lin CH Lee HC |
| author_sort | Chiu NC |
| collection | DOAJ |
| description | Nan-Chang Chiu,1,2,* Chien-Yu Lin,3,* Hsin Chi,1 Chun-Yan Yeung,1,2 Wei-Hsin Ting,1 Wai-Tao Chan,1 Chuen-Bin Jiang,1 Sung-Tse Li,3,4 Chao-Hsu Lin,3 Hung-Chang Lee1,2 1Department of Pediatrics, MacKay Children’s Hospital, 2Department of Medicine, MacKay Junior College of Medicine, Nursing and Management, Taipei, 3Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City, 4Department of Statistics and Information Science, Fu Jen Catholic University, New Taipei, Taiwan *These authors contributed equally to this work Purpose: The long-term impact of Helicobacter pylori infection is complex, and concerns about the need for eradication exist. We conducted this case control study to investigate the association between H. pylori infection and failure to thrive (FTT).Patients and methods: From January 2009 to December 2011, 53 children with FTT group and matched children with the same sex and age and similar socioeconomic status without FTT (control group) were enrolled. A questionnaire was administered to the parents/guardian, and a 13C-urea breath test was performed to detect H. pylori infection.Results: We found that the total prevalence of H. pylori infection was 29.2% and that there was no association between FTT and H. pylori infection (FTT group: 32%; control group: 26.4%; P=0.67). Short stature was more common in the FTT group and abdominal pain in the control group (FTT group: 37.7%; control group: 11.3%; P=0.003). In a comparison between the H. pylori-positive and -negative groups, abdominal pain (87.1% vs 64%; P=0.032) and the frequency of endoscopy (74.2% vs 32%; P<0.001) were significantly more common in the H. pylori-positive group.Conclusion: We found that children with H. pylori infection are at an increased risk for abdominal pain and that FTT is not associated with H. pylori infection. The decision for eradication should be evaluated carefully and individualized. Keywords: Helicobacter pylori, 13C-urea breath test, failure to thrive, growth retardation, children |
| first_indexed | 2024-12-20T22:45:05Z |
| format | Article |
| id | doaj.art-a7e23732b42344daae2c55c977422033 |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-20T22:45:05Z |
| publishDate | 2017-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-a7e23732b42344daae2c55c9774220332022-12-21T19:24:24ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2017-02-01Volume 1327327831521Helicobacter pylori infection is not associated with failure to thrive: a case–control studyChiu NCLin CYChi HYeung CYTing WHChan WTJiang CBLi STLin CHLee HCNan-Chang Chiu,1,2,* Chien-Yu Lin,3,* Hsin Chi,1 Chun-Yan Yeung,1,2 Wei-Hsin Ting,1 Wai-Tao Chan,1 Chuen-Bin Jiang,1 Sung-Tse Li,3,4 Chao-Hsu Lin,3 Hung-Chang Lee1,2 1Department of Pediatrics, MacKay Children’s Hospital, 2Department of Medicine, MacKay Junior College of Medicine, Nursing and Management, Taipei, 3Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu City, 4Department of Statistics and Information Science, Fu Jen Catholic University, New Taipei, Taiwan *These authors contributed equally to this work Purpose: The long-term impact of Helicobacter pylori infection is complex, and concerns about the need for eradication exist. We conducted this case control study to investigate the association between H. pylori infection and failure to thrive (FTT).Patients and methods: From January 2009 to December 2011, 53 children with FTT group and matched children with the same sex and age and similar socioeconomic status without FTT (control group) were enrolled. A questionnaire was administered to the parents/guardian, and a 13C-urea breath test was performed to detect H. pylori infection.Results: We found that the total prevalence of H. pylori infection was 29.2% and that there was no association between FTT and H. pylori infection (FTT group: 32%; control group: 26.4%; P=0.67). Short stature was more common in the FTT group and abdominal pain in the control group (FTT group: 37.7%; control group: 11.3%; P=0.003). In a comparison between the H. pylori-positive and -negative groups, abdominal pain (87.1% vs 64%; P=0.032) and the frequency of endoscopy (74.2% vs 32%; P<0.001) were significantly more common in the H. pylori-positive group.Conclusion: We found that children with H. pylori infection are at an increased risk for abdominal pain and that FTT is not associated with H. pylori infection. The decision for eradication should be evaluated carefully and individualized. Keywords: Helicobacter pylori, 13C-urea breath test, failure to thrive, growth retardation, childrenhttps://www.dovepress.com/helicobacter-pylori-infection-is-not-associated-with-failure-to-thrive-peer-reviewed-article-TCRMHelicobacter pylori13C-urea breath testfailure to thrivegrowth retardationchildren |
| spellingShingle | Chiu NC Lin CY Chi H Yeung CY Ting WH Chan WT Jiang CB Li ST Lin CH Lee HC Helicobacter pylori infection is not associated with failure to thrive: a case–control study Therapeutics and Clinical Risk Management Helicobacter pylori 13C-urea breath test failure to thrive growth retardation children |
| title | Helicobacter pylori infection is not associated with failure to thrive: a case–control study |
| title_full | Helicobacter pylori infection is not associated with failure to thrive: a case–control study |
| title_fullStr | Helicobacter pylori infection is not associated with failure to thrive: a case–control study |
| title_full_unstemmed | Helicobacter pylori infection is not associated with failure to thrive: a case–control study |
| title_short | Helicobacter pylori infection is not associated with failure to thrive: a case–control study |
| title_sort | helicobacter pylori infection is not associated with failure to thrive a case ndash control study |
| topic | Helicobacter pylori 13C-urea breath test failure to thrive growth retardation children |
| url | https://www.dovepress.com/helicobacter-pylori-infection-is-not-associated-with-failure-to-thrive-peer-reviewed-article-TCRM |
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