Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives

Automation empowers self-sustainable adaptive processes and personalized services in many industries. The implementation of the integrated healthcare paradigm built on Health 4.0 is expected to transform any area in medicine due to the lightning-speed advances in control, robotics, artificial intell...

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Main Authors: Mihaela Ghita, Martine Neckebroek, Cristina Muresan, Dana Copot
Format: Article
Language:English
Published: IEEE 2020-01-01
Series:IEEE Access
Subjects:
Online Access:https://ieeexplore.ieee.org/document/9257370/
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author Mihaela Ghita
Martine Neckebroek
Cristina Muresan
Dana Copot
author_facet Mihaela Ghita
Martine Neckebroek
Cristina Muresan
Dana Copot
author_sort Mihaela Ghita
collection DOAJ
description Automation empowers self-sustainable adaptive processes and personalized services in many industries. The implementation of the integrated healthcare paradigm built on Health 4.0 is expected to transform any area in medicine due to the lightning-speed advances in control, robotics, artificial intelligence, sensors etc. The two objectives of this article, as addressed to different entities, are: i) to raise awareness throughout the anesthesiologists about the usefulness of integrating automation and data exchange in their clinical practice for providing increased attention to alarming situations, ii) to provide the actualized insights of drug-delivery research in order to create an opening horizon towards precision medicine with significantly improved human outcomes. This article presents a concise overview on the recent evolution of closed-loop anesthesia delivery control systems by means of control strategies, depth of anesthesia monitors, patient modelling, safety systems, and validation in clinical trials. For decades, anesthesia control has been in the midst of transformative changes, going from simple controllers to integrative strategies of two or more components, but not achieving yet the breakthrough of an integrated system. However, the scientific advances that happen at high speed need a modern review to identify the current technological gaps, societal implications, and implementation barriers. This article provides a good basis for control research in clinical anesthesia to endorse new challenges for intelligent systems towards individualized patient care. At this connection point of clinical and engineering frameworks through (semi-) automation, the following can be granted: patient safety, economical efficiency, and clinicians' efficacy.
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spelling doaj.art-a7e3d11e50aa40b6a49ed5552454aab62022-12-21T22:55:28ZengIEEEIEEE Access2169-35362020-01-01820626420627910.1109/ACCESS.2020.30377259257370Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and PerspectivesMihaela Ghita0https://orcid.org/0000-0003-0391-3270Martine Neckebroek1Cristina Muresan2https://orcid.org/0000-0003-2301-4133Dana Copot3https://orcid.org/0000-0002-6010-830XDepartment of Electromechanical, Systems and Metal Engineering, Research Group of Dynamical Systems and Control, Ghent University, Ghent, BelgiumDepartment of Anesthesia, Ghent University Hospital, Ghent, BelgiumDepartment of Automation, Technical University of Cluj-Napoca, Cluj-Napoca, RomaniaDepartment of Electromechanical, Systems and Metal Engineering, Research Group of Dynamical Systems and Control, Ghent University, Ghent, BelgiumAutomation empowers self-sustainable adaptive processes and personalized services in many industries. The implementation of the integrated healthcare paradigm built on Health 4.0 is expected to transform any area in medicine due to the lightning-speed advances in control, robotics, artificial intelligence, sensors etc. The two objectives of this article, as addressed to different entities, are: i) to raise awareness throughout the anesthesiologists about the usefulness of integrating automation and data exchange in their clinical practice for providing increased attention to alarming situations, ii) to provide the actualized insights of drug-delivery research in order to create an opening horizon towards precision medicine with significantly improved human outcomes. This article presents a concise overview on the recent evolution of closed-loop anesthesia delivery control systems by means of control strategies, depth of anesthesia monitors, patient modelling, safety systems, and validation in clinical trials. For decades, anesthesia control has been in the midst of transformative changes, going from simple controllers to integrative strategies of two or more components, but not achieving yet the breakthrough of an integrated system. However, the scientific advances that happen at high speed need a modern review to identify the current technological gaps, societal implications, and implementation barriers. This article provides a good basis for control research in clinical anesthesia to endorse new challenges for intelligent systems towards individualized patient care. At this connection point of clinical and engineering frameworks through (semi-) automation, the following can be granted: patient safety, economical efficiency, and clinicians' efficacy.https://ieeexplore.ieee.org/document/9257370/Closed-loop controldrug-delivery controlanesthesia(semi-)automated anesthesia deliverycyber physical medical systemsdecision support systems
spellingShingle Mihaela Ghita
Martine Neckebroek
Cristina Muresan
Dana Copot
Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives
IEEE Access
Closed-loop control
drug-delivery control
anesthesia
(semi-)automated anesthesia delivery
cyber physical medical systems
decision support systems
title Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives
title_full Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives
title_fullStr Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives
title_full_unstemmed Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives
title_short Closed-Loop Control of Anesthesia: Survey on Actual Trends, Challenges and Perspectives
title_sort closed loop control of anesthesia survey on actual trends challenges and perspectives
topic Closed-loop control
drug-delivery control
anesthesia
(semi-)automated anesthesia delivery
cyber physical medical systems
decision support systems
url https://ieeexplore.ieee.org/document/9257370/
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