Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species

Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species

Rationale: Recently, abundant axial tubule (AT) membrane structures were identified deep inside atrial myocytes (AMs). Upon excitation, ATs rapidly activate intracellular Ca2+ release and sarcomeric contraction through extensive AT junctions, a cell-specific atrial mechanism. While AT junctions with...

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Bibliographic Details
Main Authors: Sören Brandenburg, Jan Pawlowitz, Funsho E. Fakuade, Daniel Kownatzki-Danger, Tobias Kohl, Gyuzel Y. Mitronova, Marina Scardigli, Jakob Neef, Constanze Schmidt, Felix Wiedmann, Francesco S. Pavone, Leonardo Sacconi, Ingo Kutschka, Samuel Sossalla, Tobias Moser, Niels Voigt, Stephan E. Lehnart
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
atria
atrial myocyte
axial tubule
calcium
heart
ryanodine receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01227/full

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