Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia
Ziad Amin,1 Habtamu Mitiku,2 Dadi Marami,2 Tadesse Shume,2 Fitsum Weldegebreal2 1Harari Health Research and Regional Laboratory, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Fitsum Weldegebreal...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-10-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/magnitude-of-multidrug-resistance-and-associated-factors-of-pulmonary--peer-reviewed-fulltext-article-IDR |
| _version_ | 1819121288819507200 |
|---|---|
| author | Amin Z Mitiku H Marami D Shume T Weldegebreal F |
| author_facet | Amin Z Mitiku H Marami D Shume T Weldegebreal F |
| author_sort | Amin Z |
| collection | DOAJ |
| description | Ziad Amin,1 Habtamu Mitiku,2 Dadi Marami,2 Tadesse Shume,2 Fitsum Weldegebreal2 1Harari Health Research and Regional Laboratory, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Fitsum Weldegebreal Email fwmlab2000@gmail.comBackground: In Ethiopia, multidrug resistant tuberculosis is a major public health problem. However, information is scarce regarding MDR-TB and associated factors. Objective: The study was aimed to assess the magnitude of multidrug resistance and associated factors of pulmonary tuberculosis among adult smear-positive patients in Harari regional state health facilities, eastern Ethiopia.Methods: A cross-sectional study was conducted among 395 adult smear-positive pulmonary tuberculosis patients attending health facilities from March to October 2019. Smear-positive sputum samples were collected from health facilities, and transported to Harari Health Research and Regional Laboratory, and tested for drug susceptibility using a line probe assay. Data were analyzed using Statistical Package for Social Sciences version 20. Bivariate and multivariable logistic regression analyses with 95% confidence intervals were carried out to identify factors associated with multidrug-resistant tuberculosis.Results: The overall magnitude of multidrug-resistant tuberculosis was 3.8% (15/395) (95% CI: 2.0– 5.8%). Being male (AOR = 4.9; 95% CI: 1.16, 20.5), patients with a previous history of tuberculosis (AOR = 4.9; 95% CI: 1.5, 29.6), treatment failure (AOR = 8.5; 95% CI: 1.61, 45.3), treatment default (AOR = 10.38; 95% CI: 1.86, 58.0), human immunodeficiency virus co-infection (AOR = 9.83.95% CI: 3, 21, 30.1) and a previous history of contact with multidrug-resistant tuberculosis patients (AOR = 14.4; 95% CI: 3.1, 67.6) had higher odds of multidrug-resistant tuberculosis.Conclusion: The overall magnitude of multidrug-resistant tuberculosis was high. Strengthening the tuberculosis control program by giving special attention to HIV co-infected patients, treatment failure and default, previously infected patients as well as to those individuals who have a history of contact with multidrug-resistant tuberculosis infected patients .Keywords: magnitude, multidrug resistance, pulmonary tuberculosis, eastern Ethiopia |
| first_indexed | 2024-12-22T06:34:11Z |
| format | Article |
| id | doaj.art-a7e6c537a7744f2282d54f57c89d8518 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-22T06:34:11Z |
| publishDate | 2021-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-a7e6c537a7744f2282d54f57c89d85182022-12-21T18:35:38ZengDove Medical PressInfection and Drug Resistance1178-69732021-10-01Volume 144493450070101Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern EthiopiaAmin ZMitiku HMarami DShume TWeldegebreal FZiad Amin,1 Habtamu Mitiku,2 Dadi Marami,2 Tadesse Shume,2 Fitsum Weldegebreal2 1Harari Health Research and Regional Laboratory, Harar, Ethiopia; 2Department of Medical Laboratory Sciences, College of Health and Medical Science, Haramaya University, Harar, EthiopiaCorrespondence: Fitsum Weldegebreal Email fwmlab2000@gmail.comBackground: In Ethiopia, multidrug resistant tuberculosis is a major public health problem. However, information is scarce regarding MDR-TB and associated factors. Objective: The study was aimed to assess the magnitude of multidrug resistance and associated factors of pulmonary tuberculosis among adult smear-positive patients in Harari regional state health facilities, eastern Ethiopia.Methods: A cross-sectional study was conducted among 395 adult smear-positive pulmonary tuberculosis patients attending health facilities from March to October 2019. Smear-positive sputum samples were collected from health facilities, and transported to Harari Health Research and Regional Laboratory, and tested for drug susceptibility using a line probe assay. Data were analyzed using Statistical Package for Social Sciences version 20. Bivariate and multivariable logistic regression analyses with 95% confidence intervals were carried out to identify factors associated with multidrug-resistant tuberculosis.Results: The overall magnitude of multidrug-resistant tuberculosis was 3.8% (15/395) (95% CI: 2.0– 5.8%). Being male (AOR = 4.9; 95% CI: 1.16, 20.5), patients with a previous history of tuberculosis (AOR = 4.9; 95% CI: 1.5, 29.6), treatment failure (AOR = 8.5; 95% CI: 1.61, 45.3), treatment default (AOR = 10.38; 95% CI: 1.86, 58.0), human immunodeficiency virus co-infection (AOR = 9.83.95% CI: 3, 21, 30.1) and a previous history of contact with multidrug-resistant tuberculosis patients (AOR = 14.4; 95% CI: 3.1, 67.6) had higher odds of multidrug-resistant tuberculosis.Conclusion: The overall magnitude of multidrug-resistant tuberculosis was high. Strengthening the tuberculosis control program by giving special attention to HIV co-infected patients, treatment failure and default, previously infected patients as well as to those individuals who have a history of contact with multidrug-resistant tuberculosis infected patients .Keywords: magnitude, multidrug resistance, pulmonary tuberculosis, eastern Ethiopiahttps://www.dovepress.com/magnitude-of-multidrug-resistance-and-associated-factors-of-pulmonary--peer-reviewed-fulltext-article-IDRmagnitudemultidrug resistancepulmonary tuberculosiseastern ethiopia |
| spellingShingle | Amin Z Mitiku H Marami D Shume T Weldegebreal F Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia Infection and Drug Resistance magnitude multidrug resistance pulmonary tuberculosis eastern ethiopia |
| title | Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia |
| title_full | Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia |
| title_fullStr | Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia |
| title_full_unstemmed | Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia |
| title_short | Magnitude of Multidrug Resistance and Associated Factors of Pulmonary Tuberculosis Among Adult Smear Positive Patients in Eastern Ethiopia |
| title_sort | magnitude of multidrug resistance and associated factors of pulmonary tuberculosis among adult smear positive patients in eastern ethiopia |
| topic | magnitude multidrug resistance pulmonary tuberculosis eastern ethiopia |
| url | https://www.dovepress.com/magnitude-of-multidrug-resistance-and-associated-factors-of-pulmonary--peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT aminz magnitudeofmultidrugresistanceandassociatedfactorsofpulmonarytuberculosisamongadultsmearpositivepatientsineasternethiopia AT mitikuh magnitudeofmultidrugresistanceandassociatedfactorsofpulmonarytuberculosisamongadultsmearpositivepatientsineasternethiopia AT maramid magnitudeofmultidrugresistanceandassociatedfactorsofpulmonarytuberculosisamongadultsmearpositivepatientsineasternethiopia AT shumet magnitudeofmultidrugresistanceandassociatedfactorsofpulmonarytuberculosisamongadultsmearpositivepatientsineasternethiopia AT weldegebrealf magnitudeofmultidrugresistanceandassociatedfactorsofpulmonarytuberculosisamongadultsmearpositivepatientsineasternethiopia |