The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling.
An influential model suggests that dopamine signals the difference between predicted and experienced reward. In this way, dopamine can act as a learning signal that can shape behaviors to maximize rewards and avoid punishments. Dopamine is also thought to invigorate reward seeking behavior. Loss of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00196/full |
| _version_ | 1818984501049556992 |
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| author | Crystal A Clark Alain eDagher |
| author_facet | Crystal A Clark Alain eDagher |
| author_sort | Crystal A Clark |
| collection | DOAJ |
| description | An influential model suggests that dopamine signals the difference between predicted and experienced reward. In this way, dopamine can act as a learning signal that can shape behaviors to maximize rewards and avoid punishments. Dopamine is also thought to invigorate reward seeking behavior. Loss of dopamine signaling is the major abnormality in Parkinson’s disease. Dopamine agonists have been implicated in the occurrence of impulse control disorders in Parkinson’s disease patients, the most common being pathological gambling, compulsive sexual behavior, and compulsive buying. Recently, a number of functional imaging studies investigating impulse control disorders in Parkinson’s disease have been published. Here we review this literature, and attempt to place it within a decision-making framework in which potential gains and losses are evaluated to arrive at optimum choices. We also provide a hypothetical but still incomplete model on the effect of dopamine agonist treatment on these value and risk assessments. Two of the main brain structures thought to be involved in computing aspects of reward and loss are the ventral striatum and the insula, both dopamine projection sites. Both structures are consistently implicated in functional brain imaging studies of pathological gambling in Parkinson’s disease. |
| first_indexed | 2024-12-20T18:20:00Z |
| format | Article |
| id | doaj.art-a7e6e512d1c74610b51f6de64e08df9d |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-20T18:20:00Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-a7e6e512d1c74610b51f6de64e08df9d2022-12-21T19:30:16ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-05-01810.3389/fnbeh.2014.0019691180The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling.Crystal A Clark0Alain eDagher1Montreal Neurological Institute, McGill UniversityMontreal Neurological Institute, McGill UniversityAn influential model suggests that dopamine signals the difference between predicted and experienced reward. In this way, dopamine can act as a learning signal that can shape behaviors to maximize rewards and avoid punishments. Dopamine is also thought to invigorate reward seeking behavior. Loss of dopamine signaling is the major abnormality in Parkinson’s disease. Dopamine agonists have been implicated in the occurrence of impulse control disorders in Parkinson’s disease patients, the most common being pathological gambling, compulsive sexual behavior, and compulsive buying. Recently, a number of functional imaging studies investigating impulse control disorders in Parkinson’s disease have been published. Here we review this literature, and attempt to place it within a decision-making framework in which potential gains and losses are evaluated to arrive at optimum choices. We also provide a hypothetical but still incomplete model on the effect of dopamine agonist treatment on these value and risk assessments. Two of the main brain structures thought to be involved in computing aspects of reward and loss are the ventral striatum and the insula, both dopamine projection sites. Both structures are consistently implicated in functional brain imaging studies of pathological gambling in Parkinson’s disease.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00196/fullDopamineGamblingImpulse Control DisordersimpulsivityParkinson's diseaseReward |
| spellingShingle | Crystal A Clark Alain eDagher The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling. Frontiers in Behavioral Neuroscience Dopamine Gambling Impulse Control Disorders impulsivity Parkinson's disease Reward |
| title | The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling. |
| title_full | The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling. |
| title_fullStr | The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling. |
| title_full_unstemmed | The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling. |
| title_short | The Role Of Dopamine In Risk Taking: A Specific Look At Parkinson’s Disease And Gambling. |
| title_sort | role of dopamine in risk taking a specific look at parkinson s disease and gambling |
| topic | Dopamine Gambling Impulse Control Disorders impulsivity Parkinson's disease Reward |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00196/full |
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