Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells
Cerium oxide nanoparticles (CeO2 NPs) and flavonoid curcumin that has been widely studied for treating diseases involving high reactive oxygen species (ROS). In nanotherapeutics, the particle size, shape, metal oxide dispersity and surface properties of nanocarriers are vital for drug delivery and t...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | OpenNano |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352952023000488 |
| _version_ | 1797729856875659264 |
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| author | Sarah Almofty Vijaya Ravinayagam Norah Alghamdi Wejdan Alghamdi Zainab Albazroun Layan Almulla Sultan Akhtar Ali Awad Almofleh Gazali Tanimu H. Dafalla B. Rabindran Jermy |
| author_facet | Sarah Almofty Vijaya Ravinayagam Norah Alghamdi Wejdan Alghamdi Zainab Albazroun Layan Almulla Sultan Akhtar Ali Awad Almofleh Gazali Tanimu H. Dafalla B. Rabindran Jermy |
| author_sort | Sarah Almofty |
| collection | DOAJ |
| description | Cerium oxide nanoparticles (CeO2 NPs) and flavonoid curcumin that has been widely studied for treating diseases involving high reactive oxygen species (ROS). In nanotherapeutics, the particle size, shape, metal oxide dispersity and surface properties of nanocarriers are vital for drug delivery and therapeutic efficiency. Here, cisplatin release behavior on cerium impregnated two different shaped nanocarriers, CeO2/monodispersed spherical silica (Sil) and CeO2/halloysite (Hal) nanotube was studied for potential anti-cancer therapies. For comparison, CeO2 impregnated mesoporous silica MCM-41, SBA-16, Hydroxyapatite and clay were prepared. Subsequently, the nanocomposites were coated with curcumin (25% wt/wt), and cisplatin (Cp) functionalization (5% wt/wt). 5wt%CeO2/Hal/Cp and 5wt%CeO2/Sil/Cp samples were pegylated using lyophilization technique. Physico-chemical analyses revealed the nanosized distribution of CeO2 and functionalization of cisplatin and curcumin. Cp release was studied using automated Franz cell and dialysis membrane techniques. The different structured nanocarriers delivering mechanism was studied by determining the drug kinetic release using four different kinetic models (first order, second order, Higuchi and Korsmeyer-Peppas). In vitro cytotoxicity assay of nano formulations along with free cisplatin and curcumin (Cur) were tested against the breast cancer cell line (MCF-7) for multiple timepoints by MTT assay. The results reveled the efficacy of 5wt%CeO2/Sil/Cp/Cur nanoparticles in delivering cisplatin. On the other hand, 5wt%CeO2/Hal/Cur nanoparticles enhanced the uptake of curcumin in comparison to free curcumin. Overall, pegylated CeO2/Silica nano formulation demonstrated an effective carrier to cisplatin for potential treatment of breast cancer. |
| first_indexed | 2024-03-12T11:35:44Z |
| format | Article |
| id | doaj.art-a7e7d18063374693baa3a463a00cf7e5 |
| institution | Directory Open Access Journal |
| issn | 2352-9520 |
| language | English |
| last_indexed | 2024-03-12T11:35:44Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | OpenNano |
| spelling | doaj.art-a7e7d18063374693baa3a463a00cf7e52023-09-01T05:02:42ZengElsevierOpenNano2352-95202023-09-0113100169Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cellsSarah Almofty0Vijaya Ravinayagam1Norah Alghamdi2Wejdan Alghamdi3Zainab Albazroun4Layan Almulla5Sultan Akhtar6Ali Awad Almofleh7Gazali Tanimu8H. Dafalla9B. Rabindran Jermy10Department of Stem Cell Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Corresponding authors.Deanship of Scientific Research & Department of NanoMedicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaSummer Research Program, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaSummer Research Program, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaSummer Research Program, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaSummer Research Program, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaDepartment of Biophysics Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi ArabiaSchool of Engineering, University of Manchester, Sackville Street, Manchester, Northern Ireland M60 1QD, UKCenter for Refining and Advanced Chemicals, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi ArabiaCollege of Engineering Research (CER), King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi ArabiaDepartment of NanoMedicine Research, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia; Corresponding authors.Cerium oxide nanoparticles (CeO2 NPs) and flavonoid curcumin that has been widely studied for treating diseases involving high reactive oxygen species (ROS). In nanotherapeutics, the particle size, shape, metal oxide dispersity and surface properties of nanocarriers are vital for drug delivery and therapeutic efficiency. Here, cisplatin release behavior on cerium impregnated two different shaped nanocarriers, CeO2/monodispersed spherical silica (Sil) and CeO2/halloysite (Hal) nanotube was studied for potential anti-cancer therapies. For comparison, CeO2 impregnated mesoporous silica MCM-41, SBA-16, Hydroxyapatite and clay were prepared. Subsequently, the nanocomposites were coated with curcumin (25% wt/wt), and cisplatin (Cp) functionalization (5% wt/wt). 5wt%CeO2/Hal/Cp and 5wt%CeO2/Sil/Cp samples were pegylated using lyophilization technique. Physico-chemical analyses revealed the nanosized distribution of CeO2 and functionalization of cisplatin and curcumin. Cp release was studied using automated Franz cell and dialysis membrane techniques. The different structured nanocarriers delivering mechanism was studied by determining the drug kinetic release using four different kinetic models (first order, second order, Higuchi and Korsmeyer-Peppas). In vitro cytotoxicity assay of nano formulations along with free cisplatin and curcumin (Cur) were tested against the breast cancer cell line (MCF-7) for multiple timepoints by MTT assay. The results reveled the efficacy of 5wt%CeO2/Sil/Cp/Cur nanoparticles in delivering cisplatin. On the other hand, 5wt%CeO2/Hal/Cur nanoparticles enhanced the uptake of curcumin in comparison to free curcumin. Overall, pegylated CeO2/Silica nano formulation demonstrated an effective carrier to cisplatin for potential treatment of breast cancer.http://www.sciencedirect.com/science/article/pii/S2352952023000488Cerium nanoparticlesSilicaCisplatinCurcuminHalloysiteBreast cancer |
| spellingShingle | Sarah Almofty Vijaya Ravinayagam Norah Alghamdi Wejdan Alghamdi Zainab Albazroun Layan Almulla Sultan Akhtar Ali Awad Almofleh Gazali Tanimu H. Dafalla B. Rabindran Jermy Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells OpenNano Cerium nanoparticles Silica Cisplatin Curcumin Halloysite Breast cancer |
| title | Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells |
| title_full | Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells |
| title_fullStr | Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells |
| title_full_unstemmed | Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells |
| title_short | Effect of CeO2/spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells |
| title_sort | effect of ceo2 spherical silica and halloysite nanotubes engineered for targeted drug delivery system to treat breast cancer cells |
| topic | Cerium nanoparticles Silica Cisplatin Curcumin Halloysite Breast cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2352952023000488 |
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