Nrf2/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis

Nrf2/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis

Abstract Background This study examined the effect of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway on chronic obstructive pulmonary disease (COPD) and the potential molecular mechanism. Methods A COPD mouse model was established by cigarette smoke exposure a...

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Bibliographic Details
Main Authors: Yanan Zhang, Jinxia Wang, Yuling Wang, Kai Lei
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Cardiothoracic Surgery
Subjects:
COPD
Inflammation
Nrf2/HO-1 pathway
NLRP3
Pyroptosis
Online Access:https://doi.org/10.1186/s13019-024-02530-3

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