Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart
Baccharus triptera Mart, is a widespread Compositae used in Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/Kg, p.o) did not...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1991-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600031 |
| _version_ | 1797758453381332992 |
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| author | Maria T. Gamberini L. A. Skorupa Caden Souccar Antonio J. Lapa |
| author_facet | Maria T. Gamberini L. A. Skorupa Caden Souccar Antonio J. Lapa |
| author_sort | Maria T. Gamberini |
| collection | DOAJ |
| description | Baccharus triptera Mart, is a widespread Compositae used in Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/Kg, p.o) did not alter spontaneous motor activity, sleeping time induced by barbiturates or the tailflick response in mice. The extract decreased by 40 por cento the number of writhings induced by 0.8 por cento scetic acid, i.p., but did not influence paw edema induced by carrageenan or dextran in rats WE (2g/Kg, p.o.) decreased the intestinal transit of charcoal in mice by 20//. Gastric secretion in pylorus ligated rats was reduced after treatment with WE (1 and 2 g/Kg. i.p. or intraduodenal and the gastric pH was raised. The extract (1 g/Kg, p.o.) prevented gastric ulcers induced in rats by immobilization at 4ºC, but not those induced by indomethacin (10 mg/Kg, s.c.). The results indicate that WE may relieve gastrointestinal disorders by reducing acid secretion and gastrointestinal hiperactivity. Neither analgesic nor anti-inflammatory activities were detectable. |
| first_indexed | 2024-03-12T18:30:11Z |
| format | Article |
| id | doaj.art-a7e8a14b1b424bb28edc57c094cc05a3 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:30:11Z |
| publishDate | 1991-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-a7e8a14b1b424bb28edc57c094cc05a32023-08-02T08:19:33ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601991-01-018613713910.1590/S0074-02761991000600031Inhibition of gastric secretion by a water extract from Baccharis triptera, MartMaria T. GamberiniL. A. SkorupaCaden SouccarAntonio J. LapaBaccharus triptera Mart, is a widespread Compositae used in Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/Kg, p.o) did not alter spontaneous motor activity, sleeping time induced by barbiturates or the tailflick response in mice. The extract decreased by 40 por cento the number of writhings induced by 0.8 por cento scetic acid, i.p., but did not influence paw edema induced by carrageenan or dextran in rats WE (2g/Kg, p.o.) decreased the intestinal transit of charcoal in mice by 20//. Gastric secretion in pylorus ligated rats was reduced after treatment with WE (1 and 2 g/Kg. i.p. or intraduodenal and the gastric pH was raised. The extract (1 g/Kg, p.o.) prevented gastric ulcers induced in rats by immobilization at 4ºC, but not those induced by indomethacin (10 mg/Kg, s.c.). The results indicate that WE may relieve gastrointestinal disorders by reducing acid secretion and gastrointestinal hiperactivity. Neither analgesic nor anti-inflammatory activities were detectable.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600031Baccharis tripteragastric secretionmedicinal plant |
| spellingShingle | Maria T. Gamberini L. A. Skorupa Caden Souccar Antonio J. Lapa Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart Memorias do Instituto Oswaldo Cruz Baccharis triptera gastric secretion medicinal plant |
| title | Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart |
| title_full | Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart |
| title_fullStr | Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart |
| title_full_unstemmed | Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart |
| title_short | Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart |
| title_sort | inhibition of gastric secretion by a water extract from baccharis triptera mart |
| topic | Baccharis triptera gastric secretion medicinal plant |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600031 |
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