Voluntary exercise does not always suppress lung cancer progression
Summary: Physical exercise can lower lung cancer incidence. However, its effect on lung cancer progression is less understood. Studies on exercising mice have shown decreased ectopic lung cancer growth through the secretion of interleukin-6 from muscles and the recruitment of natural killer (NK) cel...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223013755 |
| _version_ | 1797773632430145536 |
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| author | Aurelia C. Leimbacher Philipp Villiger Nina Desboeufs Mostafa A. Aboouf Monica Nanni Julia Armbruster Hyrije Ademi Pascal Flüchter Maja Ruetten Felix Gantenbein Thomas J. Haider Max Gassmann Markus Thiersch |
| author_facet | Aurelia C. Leimbacher Philipp Villiger Nina Desboeufs Mostafa A. Aboouf Monica Nanni Julia Armbruster Hyrije Ademi Pascal Flüchter Maja Ruetten Felix Gantenbein Thomas J. Haider Max Gassmann Markus Thiersch |
| author_sort | Aurelia C. Leimbacher |
| collection | DOAJ |
| description | Summary: Physical exercise can lower lung cancer incidence. However, its effect on lung cancer progression is less understood. Studies on exercising mice have shown decreased ectopic lung cancer growth through the secretion of interleukin-6 from muscles and the recruitment of natural killer (NK) cells to tumors. We asked if exercise suppresses lung cancer in an orthotopic model also. Single-housed C57Bl/6 male mice in cages with running wheels were tail vein-injected with LLC1.1 lung cancer cells, and lung tumor nodules were analyzed. Exercise did not affect lung cancer. Therefore, we also tested the effect of exercise on a subcutaneous LLC1 tumor and a tail vein-injected B16F10 melanoma model. Except for one case of excessive exercise, tumor progression was not influenced. Moderately exercising mice did not increase IL-6 or recruit NK cells to the tumor. Our data suggest that the exercise dose may dictate how efficiently the immune system is stimulated and controls tumor progression. |
| first_indexed | 2024-03-12T22:09:17Z |
| format | Article |
| id | doaj.art-a7e8c4e255d3400fba32808a850b603d |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:09:17Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a7e8c4e255d3400fba32808a850b603d2023-07-24T04:10:47ZengElsevieriScience2589-00422023-08-01268107298Voluntary exercise does not always suppress lung cancer progressionAurelia C. Leimbacher0Philipp Villiger1Nina Desboeufs2Mostafa A. Aboouf3Monica Nanni4Julia Armbruster5Hyrije Ademi6Pascal Flüchter7Maja Ruetten8Felix Gantenbein9Thomas J. Haider10Max Gassmann11Markus Thiersch12Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland; Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Physiology, University of Zurich, Zurich, SwitzerlandPathoVet AG, Pathology Diagnostic Laboratory, 8317 Tagelswangen ZH, SwitzerlandZurich Integrative Rodent Physiology (ZIRP), University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, SwitzerlandInstitute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland; Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland; Corresponding authorSummary: Physical exercise can lower lung cancer incidence. However, its effect on lung cancer progression is less understood. Studies on exercising mice have shown decreased ectopic lung cancer growth through the secretion of interleukin-6 from muscles and the recruitment of natural killer (NK) cells to tumors. We asked if exercise suppresses lung cancer in an orthotopic model also. Single-housed C57Bl/6 male mice in cages with running wheels were tail vein-injected with LLC1.1 lung cancer cells, and lung tumor nodules were analyzed. Exercise did not affect lung cancer. Therefore, we also tested the effect of exercise on a subcutaneous LLC1 tumor and a tail vein-injected B16F10 melanoma model. Except for one case of excessive exercise, tumor progression was not influenced. Moderately exercising mice did not increase IL-6 or recruit NK cells to the tumor. Our data suggest that the exercise dose may dictate how efficiently the immune system is stimulated and controls tumor progression.http://www.sciencedirect.com/science/article/pii/S2589004223013755ImmunologyCancer |
| spellingShingle | Aurelia C. Leimbacher Philipp Villiger Nina Desboeufs Mostafa A. Aboouf Monica Nanni Julia Armbruster Hyrije Ademi Pascal Flüchter Maja Ruetten Felix Gantenbein Thomas J. Haider Max Gassmann Markus Thiersch Voluntary exercise does not always suppress lung cancer progression iScience Immunology Cancer |
| title | Voluntary exercise does not always suppress lung cancer progression |
| title_full | Voluntary exercise does not always suppress lung cancer progression |
| title_fullStr | Voluntary exercise does not always suppress lung cancer progression |
| title_full_unstemmed | Voluntary exercise does not always suppress lung cancer progression |
| title_short | Voluntary exercise does not always suppress lung cancer progression |
| title_sort | voluntary exercise does not always suppress lung cancer progression |
| topic | Immunology Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223013755 |
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