Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients
This study aimed to investigate whether skeletal muscle mass estimated via brain computed tomography (CT) could predict neurological outcomes in neurocritically ill patients. This is a retrospective, single-center study. Adult patients admitted to the neurosurgical intensive care unit (ICU) from Jan...
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/1/90 |
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| author | Yun Im Lee Ryoung-Eun Ko Joonghyun Ahn Keumhee C. Carriere Jeong-Am Ryu |
| author_facet | Yun Im Lee Ryoung-Eun Ko Joonghyun Ahn Keumhee C. Carriere Jeong-Am Ryu |
| author_sort | Yun Im Lee |
| collection | DOAJ |
| description | This study aimed to investigate whether skeletal muscle mass estimated via brain computed tomography (CT) could predict neurological outcomes in neurocritically ill patients. This is a retrospective, single-center study. Adult patients admitted to the neurosurgical intensive care unit (ICU) from January 2010 to September 2019 were eligible. Cross-sectional areas of paravertebral muscles at the first cervical vertebra level (C1-CSA) and temporalis muscle thickness (TMT) on brain CT were measured to evaluate skeletal muscle mass. The primary outcome was the Glasgow Outcome Scale score at 3 months. Among 189 patients, 81 (42.9%) patients had favorable neurologic outcomes. Initial and follow-up TMT values were higher in patients with favorable neurologic outcomes compared to those with poor outcomes (<i>p</i> = 0.003 and <i>p</i> = 0.001, respectively). The initial C1-CSA/body surface area was greater in patients with poor neurological outcomes than in those with favorable outcomes (<i>p</i> = 0.029). In multivariable analysis, changes of C1-CSA and TMT were significantly associated with poor neurological outcomes. The risk of poor neurologic outcome was especially proportional to changes of C1-CSA and TMT. The follow-up skeletal muscle mass measured via brain CT at the first week from ICU admission may help predict poor neurological outcomes in neurocritically ill patients. |
| first_indexed | 2024-03-10T03:36:56Z |
| format | Article |
| id | doaj.art-a7e97050897a4d63999a702301a72545 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:36:56Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a7e97050897a4d63999a702301a725452023-11-23T11:43:28ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011119010.3390/jcm11010090Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill PatientsYun Im Lee0Ryoung-Eun Ko1Joonghyun Ahn2Keumhee C. Carriere3Jeong-Am Ryu4Department of Internal Medicine, National Cancer Center, Goyang 10408, KoreaDepartment of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaStatistic and Data Center, Clinical Research Institute, Samsung Medical Center, Seoul 06351, KoreaDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB T6G 2G1, CanadaDepartment of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaThis study aimed to investigate whether skeletal muscle mass estimated via brain computed tomography (CT) could predict neurological outcomes in neurocritically ill patients. This is a retrospective, single-center study. Adult patients admitted to the neurosurgical intensive care unit (ICU) from January 2010 to September 2019 were eligible. Cross-sectional areas of paravertebral muscles at the first cervical vertebra level (C1-CSA) and temporalis muscle thickness (TMT) on brain CT were measured to evaluate skeletal muscle mass. The primary outcome was the Glasgow Outcome Scale score at 3 months. Among 189 patients, 81 (42.9%) patients had favorable neurologic outcomes. Initial and follow-up TMT values were higher in patients with favorable neurologic outcomes compared to those with poor outcomes (<i>p</i> = 0.003 and <i>p</i> = 0.001, respectively). The initial C1-CSA/body surface area was greater in patients with poor neurological outcomes than in those with favorable outcomes (<i>p</i> = 0.029). In multivariable analysis, changes of C1-CSA and TMT were significantly associated with poor neurological outcomes. The risk of poor neurologic outcome was especially proportional to changes of C1-CSA and TMT. The follow-up skeletal muscle mass measured via brain CT at the first week from ICU admission may help predict poor neurological outcomes in neurocritically ill patients.https://www.mdpi.com/2077-0383/11/1/90neurosurgeryintensive care unitsarcopeniaskeletal muscle massbrain computed tomography |
| spellingShingle | Yun Im Lee Ryoung-Eun Ko Joonghyun Ahn Keumhee C. Carriere Jeong-Am Ryu Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients Journal of Clinical Medicine neurosurgery intensive care unit sarcopenia skeletal muscle mass brain computed tomography |
| title | Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients |
| title_full | Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients |
| title_fullStr | Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients |
| title_full_unstemmed | Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients |
| title_short | Association between Neurologic Outcomes and Changes of Muscle Mass Measured by Brain Computed Tomography in Neurocritically Ill Patients |
| title_sort | association between neurologic outcomes and changes of muscle mass measured by brain computed tomography in neurocritically ill patients |
| topic | neurosurgery intensive care unit sarcopenia skeletal muscle mass brain computed tomography |
| url | https://www.mdpi.com/2077-0383/11/1/90 |
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