Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial Films
The use of toxic crosslinking agents and reagents in the fabrication of hydrogels is a frequent issue which is particularly concerning for biomedical or food packaging applications. In this study, novel antibacterial bionanocomposite films were obtained through a simple solvent casting technique wit...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/9/1426 |
| _version_ | 1797517581452574720 |
|---|---|
| author | Paolo Pino Silvia Ronchetti Chiara Mollea Marco Sangermano Barbara Onida Francesca Bosco |
| author_facet | Paolo Pino Silvia Ronchetti Chiara Mollea Marco Sangermano Barbara Onida Francesca Bosco |
| author_sort | Paolo Pino |
| collection | DOAJ |
| description | The use of toxic crosslinking agents and reagents in the fabrication of hydrogels is a frequent issue which is particularly concerning for biomedical or food packaging applications. In this study, novel antibacterial bionanocomposite films were obtained through a simple solvent casting technique without using any crosslinking substance. Films were made from a flexible and transparent whey protein matrix containing zinc oxide nanoparticles synthesised via a wet chemical precipitation route. The physicochemical and functional properties of the ZnO nanoparticles and of the composite films were characterised, and their antibacterial activity was tested against <i>S. epidermidis</i> and <i>E. coli</i>. The synthesised ZnO nanoparticles had an average size of about 30 nm and a specific surface area of 49.5 m<sup>2</sup>/g. The swelling ratio of the bionanocomposite films increased at basic pH, which is an appealing feature in relation to the absorption of chronic wound exudate. A n-ZnO concentration-dependent antibacterial effect was observed for composite films. In particular, marked antibacterial activity was observed against <i>S. epidermidis.</i> Overall, these findings suggest that this novel material can be a promising and sustainable alternative in the design of advanced solutions for wound dressing or food packaging. |
| first_indexed | 2024-03-10T07:18:31Z |
| format | Article |
| id | doaj.art-a7eb3539b6e6474da34cda8c3550dda7 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T07:18:31Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-a7eb3539b6e6474da34cda8c3550dda72023-11-22T14:47:34ZengMDPI AGPharmaceutics1999-49232021-09-01139142610.3390/pharmaceutics13091426Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial FilmsPaolo Pino0Silvia Ronchetti1Chiara Mollea2Marco Sangermano3Barbara Onida4Francesca Bosco5Department of Applied Science and Technology, Politecnico di Torino, 10129 Turin, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, 10129 Turin, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, 10129 Turin, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, 10129 Turin, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, 10129 Turin, ItalyDepartment of Applied Science and Technology, Politecnico di Torino, 10129 Turin, ItalyThe use of toxic crosslinking agents and reagents in the fabrication of hydrogels is a frequent issue which is particularly concerning for biomedical or food packaging applications. In this study, novel antibacterial bionanocomposite films were obtained through a simple solvent casting technique without using any crosslinking substance. Films were made from a flexible and transparent whey protein matrix containing zinc oxide nanoparticles synthesised via a wet chemical precipitation route. The physicochemical and functional properties of the ZnO nanoparticles and of the composite films were characterised, and their antibacterial activity was tested against <i>S. epidermidis</i> and <i>E. coli</i>. The synthesised ZnO nanoparticles had an average size of about 30 nm and a specific surface area of 49.5 m<sup>2</sup>/g. The swelling ratio of the bionanocomposite films increased at basic pH, which is an appealing feature in relation to the absorption of chronic wound exudate. A n-ZnO concentration-dependent antibacterial effect was observed for composite films. In particular, marked antibacterial activity was observed against <i>S. epidermidis.</i> Overall, these findings suggest that this novel material can be a promising and sustainable alternative in the design of advanced solutions for wound dressing or food packaging.https://www.mdpi.com/1999-4923/13/9/1426nanocompositeantibacterialwound dressing |
| spellingShingle | Paolo Pino Silvia Ronchetti Chiara Mollea Marco Sangermano Barbara Onida Francesca Bosco Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial Films Pharmaceutics nanocomposite antibacterial wound dressing |
| title | Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial Films |
| title_full | Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial Films |
| title_fullStr | Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial Films |
| title_full_unstemmed | Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial Films |
| title_short | Whey Proteins–Zinc Oxide Bionanocomposite as Antibacterial Films |
| title_sort | whey proteins zinc oxide bionanocomposite as antibacterial films |
| topic | nanocomposite antibacterial wound dressing |
| url | https://www.mdpi.com/1999-4923/13/9/1426 |
| work_keys_str_mv | AT paolopino wheyproteinszincoxidebionanocompositeasantibacterialfilms AT silviaronchetti wheyproteinszincoxidebionanocompositeasantibacterialfilms AT chiaramollea wheyproteinszincoxidebionanocompositeasantibacterialfilms AT marcosangermano wheyproteinszincoxidebionanocompositeasantibacterialfilms AT barbaraonida wheyproteinszincoxidebionanocompositeasantibacterialfilms AT francescabosco wheyproteinszincoxidebionanocompositeasantibacterialfilms |