The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patients
Objectives: To assess the current prevalence, distribution, and main clonal types of carbapenem-resistant Enterobacterales (CRE) in the United Arab Emirates. Methods: A total of 504 CRE collected over a 9-month period in 15 hospitals were studied. Antibiotic susceptibility and the presence of common...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222002338 |
| _version_ | 1818548811076730880 |
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| author | Ágnes Sonnevend Najiba Abdulrazzaq Akela Ghazawi Jens Thomsen Greeshma Bharathan Lilla Makszin Tahir A. Rizvi Tibor Pál |
| author_facet | Ágnes Sonnevend Najiba Abdulrazzaq Akela Ghazawi Jens Thomsen Greeshma Bharathan Lilla Makszin Tahir A. Rizvi Tibor Pál |
| author_sort | Ágnes Sonnevend |
| collection | DOAJ |
| description | Objectives: To assess the current prevalence, distribution, and main clonal types of carbapenem-resistant Enterobacterales (CRE) in the United Arab Emirates. Methods: A total of 504 CRE collected over a 9-month period in 15 hospitals were studied. Antibiotic susceptibility and the presence of common carbapenemase, 16S methylase, and mobile colistin resistance genes were assessed. Selected strains forming larger clusters by pulsed field gel electrophoresis were subjected to whole genome sequencing to identify their sequence types and core genome MLST. Results: Strains expressing OXA and NDM type carbapenemases and 16S methylases were present in all major hospitals. Considerable interhospital differences were noticed, suggesting the role of specific clones. A total of three major Klebsiella pneumoniae clones (CC14, ST231, and CC147) were identified, accounting for 48.6% of all CRE. All clones were significantly more resistant than sporadic isolates. CC14 strains exhibited a significant association with Emirati patients. Conclusions: Nearly half of CRE infections in the country are due to a limited number of clones. The data indicate the possibility of interhospital transmission, combined in some hospitals with inadequate stewardship practices. The study also revealed an association of the largest, most resistant clone (CC14) with Emirati patients. The specific reasons for it should be clarified by further investigations. |
| first_indexed | 2024-12-12T08:25:09Z |
| format | Article |
| id | doaj.art-a7ec9612ee1e4c45824bd6819622b9e4 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-12T08:25:09Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a7ec9612ee1e4c45824bd6819622b9e42022-12-22T00:31:16ZengElsevierInternational Journal of Infectious Diseases1201-97122022-07-01120103112The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patientsÁgnes Sonnevend0Najiba Abdulrazzaq1Akela Ghazawi2Jens Thomsen3Greeshma Bharathan4Lilla Makszin5Tahir A. Rizvi6Tibor Pál7Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, HungaryDepartment of Medicine, Al Kuwait Hospital, Dubai, United Arab EmiratesDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesAbu Dhabi Public Health Center, Abu Dhabi, United Arab EmiratesDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al Ain, United Arab EmiratesInstitute of Bioanalysis, Faculty of Medicine, and Szentágothai Research Center, University of Pécs, Pécs, HungaryDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; Zayed Center for Health Sciences, United Arab Emirates University, United Arab EmiratesDepartment of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, Hungary; Corresponding author at: Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Szigeti út 12, Pécs 7624, Hungary.Objectives: To assess the current prevalence, distribution, and main clonal types of carbapenem-resistant Enterobacterales (CRE) in the United Arab Emirates. Methods: A total of 504 CRE collected over a 9-month period in 15 hospitals were studied. Antibiotic susceptibility and the presence of common carbapenemase, 16S methylase, and mobile colistin resistance genes were assessed. Selected strains forming larger clusters by pulsed field gel electrophoresis were subjected to whole genome sequencing to identify their sequence types and core genome MLST. Results: Strains expressing OXA and NDM type carbapenemases and 16S methylases were present in all major hospitals. Considerable interhospital differences were noticed, suggesting the role of specific clones. A total of three major Klebsiella pneumoniae clones (CC14, ST231, and CC147) were identified, accounting for 48.6% of all CRE. All clones were significantly more resistant than sporadic isolates. CC14 strains exhibited a significant association with Emirati patients. Conclusions: Nearly half of CRE infections in the country are due to a limited number of clones. The data indicate the possibility of interhospital transmission, combined in some hospitals with inadequate stewardship practices. The study also revealed an association of the largest, most resistant clone (CC14) with Emirati patients. The specific reasons for it should be clarified by further investigations.http://www.sciencedirect.com/science/article/pii/S1201971222002338Carbapenem-resistant EnterobacteralesMetallo-beta-lactamasesKlebsiella pneumoniae ST14Country-wide surveillanceMiddle East |
| spellingShingle | Ágnes Sonnevend Najiba Abdulrazzaq Akela Ghazawi Jens Thomsen Greeshma Bharathan Lilla Makszin Tahir A. Rizvi Tibor Pál The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patients International Journal of Infectious Diseases Carbapenem-resistant Enterobacterales Metallo-beta-lactamases Klebsiella pneumoniae ST14 Country-wide surveillance Middle East |
| title | The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patients |
| title_full | The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patients |
| title_fullStr | The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patients |
| title_full_unstemmed | The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patients |
| title_short | The first nationwide surveillance of carbapenem-resistant Enterobacterales in the United Arab Emirates – increased association of Klebsiella pneumoniae CC14 clone with Emirati patients |
| title_sort | first nationwide surveillance of carbapenem resistant enterobacterales in the united arab emirates increased association of klebsiella pneumoniae cc14 clone with emirati patients |
| topic | Carbapenem-resistant Enterobacterales Metallo-beta-lactamases Klebsiella pneumoniae ST14 Country-wide surveillance Middle East |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222002338 |
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