Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature review
Abstract Objective Lymphoepithelial carcinoma (LEC) accounts for 0.4% of malignant tumors of the salivary gland and 0.8% of parotid gland malignancies. Over the past 50 years, less than 300 cases have been reported in the literature. The purpose of this study was to investigate the characteristics o...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
|
| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.811 |
| _version_ | 1828794051361505280 |
|---|---|
| author | Chiung‐Tung Chou Chun‐Yen Ou Wei‐Ting Lee Heng‐Jui Hsu |
| author_facet | Chiung‐Tung Chou Chun‐Yen Ou Wei‐Ting Lee Heng‐Jui Hsu |
| author_sort | Chiung‐Tung Chou |
| collection | DOAJ |
| description | Abstract Objective Lymphoepithelial carcinoma (LEC) accounts for 0.4% of malignant tumors of the salivary gland and 0.8% of parotid gland malignancies. Over the past 50 years, less than 300 cases have been reported in the literature. The purpose of this study was to investigate the characteristics of salivary gland LEC. Methods We retrospectively reviewed the medical records and analyzed clinical data obtained from 10 patients seen at our hospital between 2005 and 2020 with salivary gland LEC. Results All patients presented with a self‐palpable, non‐tender, hard swelling, or lump near the jaw or infra‐auricular region. Most cases (n = 8) were of solitary tumors, and enhancing patterns on computed tomography mainly were homogenous (n = 8). Interestingly, eight patients tested positive for the Epstein–Barr encoding region in in situ hybridization. Still, only three patients had detectable circulating Epstein–Barr virus (EBV) DNA, and one patient had detectable EBV IgA. All patients underwent complete tumor resection, followed by radiotherapy, and six also underwent chemotherapy. Nine patients became disease‐free within 5 years, and one died due to disease 4 years after surgery. Conclusion Although rare and considered to be a high‐risk malignancy, LECs have favorable treatment outcomes. Circulating EBV DNA is still not considered a marker for preoperative assessment or postoperative treatment response. The role of EBV DNA requires further investigation. Level of Evidence: 4 |
| first_indexed | 2024-12-12T03:38:16Z |
| format | Article |
| id | doaj.art-a7ed2884f6024468a117ca2c6139efa5 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-12-12T03:38:16Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-a7ed2884f6024468a117ca2c6139efa52022-12-22T00:39:45ZengWileyLaryngoscope Investigative Otolaryngology2378-80382022-06-017377978410.1002/lio2.811Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature reviewChiung‐Tung Chou0Chun‐Yen Ou1Wei‐Ting Lee2Heng‐Jui Hsu3Department of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Otolaryngology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanAbstract Objective Lymphoepithelial carcinoma (LEC) accounts for 0.4% of malignant tumors of the salivary gland and 0.8% of parotid gland malignancies. Over the past 50 years, less than 300 cases have been reported in the literature. The purpose of this study was to investigate the characteristics of salivary gland LEC. Methods We retrospectively reviewed the medical records and analyzed clinical data obtained from 10 patients seen at our hospital between 2005 and 2020 with salivary gland LEC. Results All patients presented with a self‐palpable, non‐tender, hard swelling, or lump near the jaw or infra‐auricular region. Most cases (n = 8) were of solitary tumors, and enhancing patterns on computed tomography mainly were homogenous (n = 8). Interestingly, eight patients tested positive for the Epstein–Barr encoding region in in situ hybridization. Still, only three patients had detectable circulating Epstein–Barr virus (EBV) DNA, and one patient had detectable EBV IgA. All patients underwent complete tumor resection, followed by radiotherapy, and six also underwent chemotherapy. Nine patients became disease‐free within 5 years, and one died due to disease 4 years after surgery. Conclusion Although rare and considered to be a high‐risk malignancy, LECs have favorable treatment outcomes. Circulating EBV DNA is still not considered a marker for preoperative assessment or postoperative treatment response. The role of EBV DNA requires further investigation. Level of Evidence: 4https://doi.org/10.1002/lio2.811Epstein–Barr viruslymphoepithelial carcinomaparotid tumorsalivary gland neoplasm |
| spellingShingle | Chiung‐Tung Chou Chun‐Yen Ou Wei‐Ting Lee Heng‐Jui Hsu Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature review Laryngoscope Investigative Otolaryngology Epstein–Barr virus lymphoepithelial carcinoma parotid tumor salivary gland neoplasm |
| title | Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature review |
| title_full | Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature review |
| title_fullStr | Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature review |
| title_full_unstemmed | Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature review |
| title_short | Clinical features in salivary gland lymphoepithelial carcinoma in 10 patients: Case series and literature review |
| title_sort | clinical features in salivary gland lymphoepithelial carcinoma in 10 patients case series and literature review |
| topic | Epstein–Barr virus lymphoepithelial carcinoma parotid tumor salivary gland neoplasm |
| url | https://doi.org/10.1002/lio2.811 |
| work_keys_str_mv | AT chiungtungchou clinicalfeaturesinsalivaryglandlymphoepithelialcarcinomain10patientscaseseriesandliteraturereview AT chunyenou clinicalfeaturesinsalivaryglandlymphoepithelialcarcinomain10patientscaseseriesandliteraturereview AT weitinglee clinicalfeaturesinsalivaryglandlymphoepithelialcarcinomain10patientscaseseriesandliteraturereview AT hengjuihsu clinicalfeaturesinsalivaryglandlymphoepithelialcarcinomain10patientscaseseriesandliteraturereview |