Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine
Tools and methods of precision medicine are developing rapidly, through both iterative discoveries enabled by innovations in biomedical research (e.g., genome editing, synthetic biology, bioengineered devices). These are strengthened by advancements in information technology and the increasing body...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1364703/full |
| _version_ | 1797256576064552960 |
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| author | Diane DiEuliis James J. Giordano James J. Giordano James J. Giordano |
| author_facet | Diane DiEuliis James J. Giordano James J. Giordano James J. Giordano |
| author_sort | Diane DiEuliis |
| collection | DOAJ |
| description | Tools and methods of precision medicine are developing rapidly, through both iterative discoveries enabled by innovations in biomedical research (e.g., genome editing, synthetic biology, bioengineered devices). These are strengthened by advancements in information technology and the increasing body of data—as assimilated, analyzed, and made accessible—and affectable—through current and emerging cyber—and systems- technologies. Taken together, these approaches afford ever greater volume and availability of individual and collective human data. Machine learning and/or artificial intelligence approaches are broadening this dual use risk; and in the aftermath of COVID-19, there is growing incentive and impetus to gather more biological data from individuals and their environments on a routine basis. By engaging these data—and the interventions that are based upon them, precision medicine offer promise of highly individualized treatments for disease and injury, optimization of structure and function, and concomitantly, the potential for (mis) using data to incur harm. This double-edged blade of benefit and risk obligates the need to safeguard human data from purloinment, through systems, guidelines and policies of a novel discipline, cyberbiosecurity, which, as coupled to ethical precepts, aims to protect human privacy, agency, and safety in ways that remain apace with scientific and technological advances in biomedicine. Herein, current capabilities and trajectories precision medicine are described as relevant to their dual use potential, and approaches to biodata security (viz.- cyberbiosecurity) are proposed and discussed. |
| first_indexed | 2024-04-24T22:23:56Z |
| format | Article |
| id | doaj.art-a7f115ef980848158c36a2f06b29f593 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-24T22:23:56Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-a7f115ef980848158c36a2f06b29f5932024-03-20T04:34:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-03-011110.3389/fmed.2024.13647031364703Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicineDiane DiEuliis0James J. Giordano1James J. Giordano2James J. Giordano3Center for the Study of Weapons of Mass Destruction, National Defense University, Washington, DC, United StatesDepartments of Neurology and Biochemistry, Georgetown University Medical Center, Washington, DC, United StatesDefense Medical Ethics Center, Uniformed Services University of the Health Sciences, Bethesda, MD, United StatesSimon Center for the Professional Military Ethic, United States Military Academy, West Point, NY, United StatesTools and methods of precision medicine are developing rapidly, through both iterative discoveries enabled by innovations in biomedical research (e.g., genome editing, synthetic biology, bioengineered devices). These are strengthened by advancements in information technology and the increasing body of data—as assimilated, analyzed, and made accessible—and affectable—through current and emerging cyber—and systems- technologies. Taken together, these approaches afford ever greater volume and availability of individual and collective human data. Machine learning and/or artificial intelligence approaches are broadening this dual use risk; and in the aftermath of COVID-19, there is growing incentive and impetus to gather more biological data from individuals and their environments on a routine basis. By engaging these data—and the interventions that are based upon them, precision medicine offer promise of highly individualized treatments for disease and injury, optimization of structure and function, and concomitantly, the potential for (mis) using data to incur harm. This double-edged blade of benefit and risk obligates the need to safeguard human data from purloinment, through systems, guidelines and policies of a novel discipline, cyberbiosecurity, which, as coupled to ethical precepts, aims to protect human privacy, agency, and safety in ways that remain apace with scientific and technological advances in biomedicine. Herein, current capabilities and trajectories precision medicine are described as relevant to their dual use potential, and approaches to biodata security (viz.- cyberbiosecurity) are proposed and discussed.https://www.frontiersin.org/articles/10.3389/fmed.2024.1364703/fullprecision medicinebiodatabioweaponscyberbiosecuritybiodefense |
| spellingShingle | Diane DiEuliis James J. Giordano James J. Giordano James J. Giordano Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine Frontiers in Medicine precision medicine biodata bioweapons cyberbiosecurity biodefense |
| title | Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine |
| title_full | Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine |
| title_fullStr | Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine |
| title_full_unstemmed | Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine |
| title_short | Safely balancing a double-edged blade: identifying and mitigating emerging biosecurity risks in precision medicine |
| title_sort | safely balancing a double edged blade identifying and mitigating emerging biosecurity risks in precision medicine |
| topic | precision medicine biodata bioweapons cyberbiosecurity biodefense |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1364703/full |
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