Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration
Low back pain is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is the primary clinical risk factor for low back pain and the pathological cause of disc herniation, spinal stenosis, and spinal deformity. A possible approach to improve the clinical practice of IDD-r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/9/2467 |
| _version_ | 1797581181034692608 |
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| author | Xiaotian Du Kejiong Liang Shili Ding Haifei Shi |
| author_facet | Xiaotian Du Kejiong Liang Shili Ding Haifei Shi |
| author_sort | Xiaotian Du |
| collection | DOAJ |
| description | Low back pain is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is the primary clinical risk factor for low back pain and the pathological cause of disc herniation, spinal stenosis, and spinal deformity. A possible approach to improve the clinical practice of IDD-related diseases is to incorporate biomarkers in diagnosis, therapeutic intervention, and prognosis prediction. IDD pathology is still unclear. Regarding molecular mechanisms, cellular signaling pathways constitute a complex network of signaling pathways that coordinate cell survival, proliferation, differentiation, and metabolism. Recently, stem cells have shown great potential in clinical applications for IDD. In this review, the roles of multiple signaling pathways and related stem cell treatment in IDD are summarized and described. This review seeks to investigate the mechanisms and potential therapeutic effects of stem cells in IDD and identify new therapeutic treatments for IDD-related disorders. |
| first_indexed | 2024-03-10T23:00:34Z |
| format | Article |
| id | doaj.art-a7f274ff8e4a451f9af8754a37f90897 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T23:00:34Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a7f274ff8e4a451f9af8754a37f908972023-11-19T09:41:44ZengMDPI AGBiomedicines2227-90592023-09-01119246710.3390/biomedicines11092467Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc DegenerationXiaotian Du0Kejiong Liang1Shili Ding2Haifei Shi3Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaLow back pain is the leading cause of disability worldwide. Intervertebral disc degeneration (IDD) is the primary clinical risk factor for low back pain and the pathological cause of disc herniation, spinal stenosis, and spinal deformity. A possible approach to improve the clinical practice of IDD-related diseases is to incorporate biomarkers in diagnosis, therapeutic intervention, and prognosis prediction. IDD pathology is still unclear. Regarding molecular mechanisms, cellular signaling pathways constitute a complex network of signaling pathways that coordinate cell survival, proliferation, differentiation, and metabolism. Recently, stem cells have shown great potential in clinical applications for IDD. In this review, the roles of multiple signaling pathways and related stem cell treatment in IDD are summarized and described. This review seeks to investigate the mechanisms and potential therapeutic effects of stem cells in IDD and identify new therapeutic treatments for IDD-related disorders.https://www.mdpi.com/2227-9059/11/9/2467intervertebral disctissue degenerationsignaling pathwaystem cell treatment |
| spellingShingle | Xiaotian Du Kejiong Liang Shili Ding Haifei Shi Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration Biomedicines intervertebral disc tissue degeneration signaling pathway stem cell treatment |
| title | Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration |
| title_full | Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration |
| title_fullStr | Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration |
| title_full_unstemmed | Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration |
| title_short | Signaling Mechanisms of Stem Cell Therapy for Intervertebral Disc Degeneration |
| title_sort | signaling mechanisms of stem cell therapy for intervertebral disc degeneration |
| topic | intervertebral disc tissue degeneration signaling pathway stem cell treatment |
| url | https://www.mdpi.com/2227-9059/11/9/2467 |
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