Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome
This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely...
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2023-01-01
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| Series: | Global Medical Genetics |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761489 |
| _version_ | 1797938830103281664 |
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| author | Darja Kanduc |
| author_facet | Darja Kanduc |
| author_sort | Darja Kanduc |
| collection | DOAJ |
| description | This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely and repeatedly distributed among 3,762 human proteins implicated in crucial fundamental cellular functions. The data can have implications for anti-RSV vaccines. Indeed, the high level of molecular mimicry can lead to cross-reactivity and autoimmunity, and invites to follow safer vaccinal protocols based on pentapeptide sequences uniquely present in the viral antigen. |
| first_indexed | 2024-04-10T19:06:59Z |
| format | Article |
| id | doaj.art-a7f30125ed5043c6aa5bd23c3dcad2c1 |
| institution | Directory Open Access Journal |
| issn | 2699-9404 |
| language | English |
| last_indexed | 2024-04-10T19:06:59Z |
| publishDate | 2023-01-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Global Medical Genetics |
| spelling | doaj.art-a7f30125ed5043c6aa5bd23c3dcad2c12023-01-31T00:17:33ZengGeorg Thieme Verlag KGGlobal Medical Genetics2699-94042023-01-011001192110.1055/s-0043-1761489Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human ProteomeDarja Kanduc0Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Bari, ItalyThis study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely and repeatedly distributed among 3,762 human proteins implicated in crucial fundamental cellular functions. The data can have implications for anti-RSV vaccines. Indeed, the high level of molecular mimicry can lead to cross-reactivity and autoimmunity, and invites to follow safer vaccinal protocols based on pentapeptide sequences uniquely present in the viral antigen.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761489molecular mimicryrsv fanti-rsv vaccines |
| spellingShingle | Darja Kanduc Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome Global Medical Genetics molecular mimicry rsv f anti-rsv vaccines |
| title | Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome |
| title_full | Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome |
| title_fullStr | Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome |
| title_full_unstemmed | Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome |
| title_short | Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome |
| title_sort | molecular mimicry between respiratory syncytial virus f antigen and the human proteome |
| topic | molecular mimicry rsv f anti-rsv vaccines |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1761489 |
| work_keys_str_mv | AT darjakanduc molecularmimicrybetweenrespiratorysyncytialvirusfantigenandthehumanproteome |