Current Clinical Landscape and Global Potential of Bacteriophage Therapy
In response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been known for their potential clinical utility in lysing bacteria for almost a century. Social pressures and the concomitant introduction of antibi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/4/1020 |
| _version_ | 1797603152221962240 |
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| author | Nicole Marie Hitchcock Danielle Devequi Gomes Nunes Job Shiach Katharine Valeria Saraiva Hodel Josiane Dantas Viana Barbosa Leticia Alencar Pereira Rodrigues Brahm Seymour Coler Milena Botelho Pereira Soares Roberto Badaró |
| author_facet | Nicole Marie Hitchcock Danielle Devequi Gomes Nunes Job Shiach Katharine Valeria Saraiva Hodel Josiane Dantas Viana Barbosa Leticia Alencar Pereira Rodrigues Brahm Seymour Coler Milena Botelho Pereira Soares Roberto Badaró |
| author_sort | Nicole Marie Hitchcock |
| collection | DOAJ |
| description | In response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been known for their potential clinical utility in lysing bacteria for almost a century. Social pressures and the concomitant introduction of antibiotics in the mid-1900s hindered the widespread adoption of these naturally occurring bactericides. Recently, however, phage therapy has re-emerged as a promising strategy for combatting antimicrobial resistance. A unique mechanism of action and cost-effective production promotes phages as an ideal solution for addressing antibiotic-resistant bacterial infections, particularly in lower- and middle-income countries. As the number of phage-related research labs worldwide continues to grow, it will be increasingly important to encourage the expansion of well-developed clinical trials, the standardization of the production and storage of phage cocktails, and the advancement of international collaboration. In this review, we discuss the history, benefits, and limitations of bacteriophage research and its current role in the setting of addressing antimicrobial resistance with a specific focus on active clinical trials and case reports of phage therapy administration. |
| first_indexed | 2024-03-11T04:26:23Z |
| format | Article |
| id | doaj.art-a7f4d6eac733479da7658c27c4b8c2fe |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:23Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a7f4d6eac733479da7658c27c4b8c2fe2023-11-17T21:47:04ZengMDPI AGViruses1999-49152023-04-01154102010.3390/v15041020Current Clinical Landscape and Global Potential of Bacteriophage TherapyNicole Marie Hitchcock0Danielle Devequi Gomes Nunes1Job Shiach2Katharine Valeria Saraiva Hodel3Josiane Dantas Viana Barbosa4Leticia Alencar Pereira Rodrigues5Brahm Seymour Coler6Milena Botelho Pereira Soares7Roberto Badaró8School of Medicine, University of Missouri, Columbia, MO 65201, USASENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, BrazilSchool of Medicine, University of California San Diego, San Diego, CA 92093, USASENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, BrazilElson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USASENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI/CIMATEC, Salvador 41650-010, BA, BrazilIn response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been known for their potential clinical utility in lysing bacteria for almost a century. Social pressures and the concomitant introduction of antibiotics in the mid-1900s hindered the widespread adoption of these naturally occurring bactericides. Recently, however, phage therapy has re-emerged as a promising strategy for combatting antimicrobial resistance. A unique mechanism of action and cost-effective production promotes phages as an ideal solution for addressing antibiotic-resistant bacterial infections, particularly in lower- and middle-income countries. As the number of phage-related research labs worldwide continues to grow, it will be increasingly important to encourage the expansion of well-developed clinical trials, the standardization of the production and storage of phage cocktails, and the advancement of international collaboration. In this review, we discuss the history, benefits, and limitations of bacteriophage research and its current role in the setting of addressing antimicrobial resistance with a specific focus on active clinical trials and case reports of phage therapy administration.https://www.mdpi.com/1999-4915/15/4/1020bacteriophagesantimicrobial resistancephage therapyreview |
| spellingShingle | Nicole Marie Hitchcock Danielle Devequi Gomes Nunes Job Shiach Katharine Valeria Saraiva Hodel Josiane Dantas Viana Barbosa Leticia Alencar Pereira Rodrigues Brahm Seymour Coler Milena Botelho Pereira Soares Roberto Badaró Current Clinical Landscape and Global Potential of Bacteriophage Therapy Viruses bacteriophages antimicrobial resistance phage therapy review |
| title | Current Clinical Landscape and Global Potential of Bacteriophage Therapy |
| title_full | Current Clinical Landscape and Global Potential of Bacteriophage Therapy |
| title_fullStr | Current Clinical Landscape and Global Potential of Bacteriophage Therapy |
| title_full_unstemmed | Current Clinical Landscape and Global Potential of Bacteriophage Therapy |
| title_short | Current Clinical Landscape and Global Potential of Bacteriophage Therapy |
| title_sort | current clinical landscape and global potential of bacteriophage therapy |
| topic | bacteriophages antimicrobial resistance phage therapy review |
| url | https://www.mdpi.com/1999-4915/15/4/1020 |
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