Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV

Development of a Transdermal Delivery System for Tenofovir Alafenamide, a Prodrug of Tenofovir with Potent Antiviral Activity Against HIV and HBV

Tenofovir alafenamide (TAF) is an effective nucleotide reverse transcriptase inhibitor that is used in the treatment of HIV-1 and HBV. Currently, it is being investigated for HIV prophylaxis. Oral TAF regimens require daily intake, which hampers adherence and increases the possibility of viral resis...

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Bibliographic Details
Main Authors: Ashana Puri, Sonalika A. Bhattaccharjee, Wei Zhang, Meredith Clark, Onkar N. Singh, Gustavo F. Doncel, Ajay K. Banga
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Pharmaceutics
Subjects:
transdermal patch
tenofovir alafenamide
acrylate adhesive
in vitro permeation
silicone adhesive
suspension patch
Online Access:https://www.mdpi.com/1999-4923/11/4/173

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