Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data
BackgroundDespite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to evaluate the effe...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1156522/full |
| _version_ | 1797855280267001856 |
|---|---|
| author | Lin Liu Yuzhou Xue Yangmei Chen Tingqiao Chen Judan Zhong Xinyi Shao Jin Chen |
| author_facet | Lin Liu Yuzhou Xue Yangmei Chen Tingqiao Chen Judan Zhong Xinyi Shao Jin Chen |
| author_sort | Lin Liu |
| collection | DOAJ |
| description | BackgroundDespite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive–compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (N = 615,396) and collected summary statistics from the largest available GWAS for depression (N = 500,199), anxiety (N = 17,310), schizophrenia (N = 130,644), OCD (N = 9,725), bipolar disorder (N = 413,466), and PTSD (N = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.ResultsThere was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, p = 0.874], anxiety (OR: 0.961, p = 0.49), OCD (OR: 0.979, p = 0.741), bipolar disorder (OR: 0.972, p = 0.261), and PTSD (OR: 1.054, p = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; p = 0.033).ConclusionThe increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented. |
| first_indexed | 2024-04-09T20:21:11Z |
| format | Article |
| id | doaj.art-a7f6ed5a39524e3fa328573b75886a34 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-09T20:21:11Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-a7f6ed5a39524e3fa328573b75886a342023-03-31T05:07:41ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-03-011110.3389/fpubh.2023.11565221156522Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association dataLin Liu0Yuzhou Xue1Yangmei Chen2Tingqiao Chen3Judan Zhong4Xinyi Shao5Jin Chen6Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaBackgroundDespite a growing body of evidence that acne impacts mental disorders, the actual causality has not been established for the possible presence of recall bias and confounders in observational studies.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to evaluate the effect of acne on the risk of six common mental disorders, i.e., depression, anxiety, schizophrenia, obsessive–compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD). We acquired genetic instruments for assessing acne from the largest genome-wide association study (GWAS) of acne (N = 615,396) and collected summary statistics from the largest available GWAS for depression (N = 500,199), anxiety (N = 17,310), schizophrenia (N = 130,644), OCD (N = 9,725), bipolar disorder (N = 413,466), and PTSD (N = 174,659). Next, we performed the two-sample MR analysis using four methods: inverse-variance weighted method, MR-Egger, weighted median, and MR pleiotropy residual sum and outliers. Sensitivity analysis was also performed for heterogeneity and pleiotropy tests.ResultsThere was no evidence of a causal impact of acne on the risk of depression [odds ratio (OR): 1.002, p = 0.874], anxiety (OR: 0.961, p = 0.49), OCD (OR: 0.979, p = 0.741), bipolar disorder (OR: 0.972, p = 0.261), and PTSD (OR: 1.054, p = 0.069). Moreover, a mild protective effect of acne against schizophrenia was observed (OR: 0.944; p = 0.033).ConclusionThe increased prevalence of mental disorders observed in patients with acne in clinical practice was caused by modifiable factors, and was not a direct outcome of acne. Therefore, strategies targeting the elimination of potential factors and minimization of the occurrence of adverse mental events in acne should be implemented.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1156522/fullacnemental disordersMendelian randomizationGWASschizophrenia |
| spellingShingle | Lin Liu Yuzhou Xue Yangmei Chen Tingqiao Chen Judan Zhong Xinyi Shao Jin Chen Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data Frontiers in Public Health acne mental disorders Mendelian randomization GWAS schizophrenia |
| title | Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data |
| title_full | Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data |
| title_fullStr | Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data |
| title_full_unstemmed | Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data |
| title_short | Acne and risk of mental disorders: A two-sample Mendelian randomization study based on large genome-wide association data |
| title_sort | acne and risk of mental disorders a two sample mendelian randomization study based on large genome wide association data |
| topic | acne mental disorders Mendelian randomization GWAS schizophrenia |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1156522/full |
| work_keys_str_mv | AT linliu acneandriskofmentaldisordersatwosamplemendelianrandomizationstudybasedonlargegenomewideassociationdata AT yuzhouxue acneandriskofmentaldisordersatwosamplemendelianrandomizationstudybasedonlargegenomewideassociationdata AT yangmeichen acneandriskofmentaldisordersatwosamplemendelianrandomizationstudybasedonlargegenomewideassociationdata AT tingqiaochen acneandriskofmentaldisordersatwosamplemendelianrandomizationstudybasedonlargegenomewideassociationdata AT judanzhong acneandriskofmentaldisordersatwosamplemendelianrandomizationstudybasedonlargegenomewideassociationdata AT xinyishao acneandriskofmentaldisordersatwosamplemendelianrandomizationstudybasedonlargegenomewideassociationdata AT jinchen acneandriskofmentaldisordersatwosamplemendelianrandomizationstudybasedonlargegenomewideassociationdata |