Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial
Knee osteoarthritis (OA) is one of the common degenerative articular disorders that are related to decreased quality of life. Currently, novel biologic therapeutic approaches are introduced in the literature for OA management. In this study, the clinical efficiency of Dextrose prolotherapy, platelet...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2020-06-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2639 |
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| author | Alireza Pishgahi Rozita Abolhasan Seyed Kazem Shakouri Mohammad Sadegh Soltani-Zangbar Shahla Dareshiri Sepideh Ranjbar Kiyakalayeh Amirghasem Khoeilar Majid Zamani Farhad Motavalli Khiavi Behzad Pourabbas Kheiraddin Amir Mehdizadeh Mehdi Yousefi |
| author_facet | Alireza Pishgahi Rozita Abolhasan Seyed Kazem Shakouri Mohammad Sadegh Soltani-Zangbar Shahla Dareshiri Sepideh Ranjbar Kiyakalayeh Amirghasem Khoeilar Majid Zamani Farhad Motavalli Khiavi Behzad Pourabbas Kheiraddin Amir Mehdizadeh Mehdi Yousefi |
| author_sort | Alireza Pishgahi |
| collection | DOAJ |
| description | Knee osteoarthritis (OA) is one of the common degenerative articular disorders that are related to decreased quality of life. Currently, novel biologic therapeutic approaches are introduced in the literature for OA management. In this study, the clinical efficiency of Dextrose prolotherapy, platelet-rich plasma (PRP) and autologous conditioned serum (ACS) injection on the level of pain and function in Knee OA were compared.
A randomized clinical trial was directed on 92 knee OA patients. Patients were randomly divided into three groups: 30 were received dextrose prolotherapy once in a week for three weeks, 30 received autologous PRP for two times with seven days interval, and in the remaining 32 patients 2ml of ACS were injected two times every seven days. Study participants were measured through the Western Ontario and McMaster Universities (WOMAC) score, the visual analogue scale (VAS), at baseline, 1 and 6 months post-intervention.
Both ACS and PRP treated patients showed improvement in pain intensity and knee function during 1 and 6 months pursue; however, this progress was more significant in the ACS group. Dextrose prolotherapy showed no substantial changes in pain and function of the affected knee in treated patients.
Treatment of Knee OA with ACS and PRP injections are associated with pain reduction and knee function improvement. Not only, ACS therapy is more effective than that of PRP, but also due to its less variability in processing and less reported side effects, it could be considered as a safe and effective non-surgical alternative for OA management. |
| first_indexed | 2024-12-11T02:56:07Z |
| format | Article |
| id | doaj.art-a7f79aa05a2c4e04b89e8e487fe2de87 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-11T02:56:07Z |
| publishDate | 2020-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-a7f79aa05a2c4e04b89e8e487fe2de872022-12-22T01:23:09ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492020-06-0119310.18502/ijaai.v19i3.34522639Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical TrialAlireza Pishgahi0Rozita Abolhasan1Seyed Kazem Shakouri2Mohammad Sadegh Soltani-Zangbar3Shahla Dareshiri4Sepideh Ranjbar Kiyakalayeh5Amirghasem Khoeilar6Majid Zamani7Farhad Motavalli Khiavi8Behzad Pourabbas Kheiraddin9Amir Mehdizadeh10Mehdi Yousefi11Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, IranStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, IranPhysical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, IranPhysical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, IranPhysical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, IranStud Road Medical Centre, Dandenong, VIC, AustraliaDepartment of Medical Laboratory Sciences, Faculty of Allied Medicine, Gonabad University of Medical Sciences, Gonabad, IranMedical Biotechnology Research Center, AJA University of Medical Sciences, Tehran, IranDepartment of Polymer Engineering, Sahand University of Technology, Tabriz, IranStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, IranStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IranKnee osteoarthritis (OA) is one of the common degenerative articular disorders that are related to decreased quality of life. Currently, novel biologic therapeutic approaches are introduced in the literature for OA management. In this study, the clinical efficiency of Dextrose prolotherapy, platelet-rich plasma (PRP) and autologous conditioned serum (ACS) injection on the level of pain and function in Knee OA were compared. A randomized clinical trial was directed on 92 knee OA patients. Patients were randomly divided into three groups: 30 were received dextrose prolotherapy once in a week for three weeks, 30 received autologous PRP for two times with seven days interval, and in the remaining 32 patients 2ml of ACS were injected two times every seven days. Study participants were measured through the Western Ontario and McMaster Universities (WOMAC) score, the visual analogue scale (VAS), at baseline, 1 and 6 months post-intervention. Both ACS and PRP treated patients showed improvement in pain intensity and knee function during 1 and 6 months pursue; however, this progress was more significant in the ACS group. Dextrose prolotherapy showed no substantial changes in pain and function of the affected knee in treated patients. Treatment of Knee OA with ACS and PRP injections are associated with pain reduction and knee function improvement. Not only, ACS therapy is more effective than that of PRP, but also due to its less variability in processing and less reported side effects, it could be considered as a safe and effective non-surgical alternative for OA management.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2639Knee osteoarthritisPlatelet rich plasma× |
| spellingShingle | Alireza Pishgahi Rozita Abolhasan Seyed Kazem Shakouri Mohammad Sadegh Soltani-Zangbar Shahla Dareshiri Sepideh Ranjbar Kiyakalayeh Amirghasem Khoeilar Majid Zamani Farhad Motavalli Khiavi Behzad Pourabbas Kheiraddin Amir Mehdizadeh Mehdi Yousefi Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial Iranian Journal of Allergy, Asthma and Immunology Knee osteoarthritis Platelet rich plasma× |
| title | Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial |
| title_full | Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial |
| title_fullStr | Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial |
| title_full_unstemmed | Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial |
| title_short | Effect of Dextrose Prolotherapy, Platelet Rich Plasma and Autologous Conditioned Serum on Knee Osteoarthritis: A Randomized Clinical Trial |
| title_sort | effect of dextrose prolotherapy platelet rich plasma and autologous conditioned serum on knee osteoarthritis a randomized clinical trial |
| topic | Knee osteoarthritis Platelet rich plasma× |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2639 |
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