Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and Beyond

In recent decades, artificial intelligence (AI) tools have been applied in many medical fields, opening the possibility of finding novel solutions for managing very complex and multifactorial problems, such as those commonly encountered in radiotherapy (RT). We conducted a PubMed and Scopus search t...

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Main Authors: Miriam Santoro, Silvia Strolin, Giulia Paolani, Giuseppe Della Gala, Alessandro Bartoloni, Cinzia Giacometti, Ilario Ammendolia, Alessio Giuseppe Morganti, Lidia Strigari
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Applied Sciences
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Online Access:https://www.mdpi.com/2076-3417/12/7/3223
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author Miriam Santoro
Silvia Strolin
Giulia Paolani
Giuseppe Della Gala
Alessandro Bartoloni
Cinzia Giacometti
Ilario Ammendolia
Alessio Giuseppe Morganti
Lidia Strigari
author_facet Miriam Santoro
Silvia Strolin
Giulia Paolani
Giuseppe Della Gala
Alessandro Bartoloni
Cinzia Giacometti
Ilario Ammendolia
Alessio Giuseppe Morganti
Lidia Strigari
author_sort Miriam Santoro
collection DOAJ
description In recent decades, artificial intelligence (AI) tools have been applied in many medical fields, opening the possibility of finding novel solutions for managing very complex and multifactorial problems, such as those commonly encountered in radiotherapy (RT). We conducted a PubMed and Scopus search to identify the AI application field in RT limited to the last four years. In total, 1824 original papers were identified, and 921 were analyzed by considering the phase of the RT workflow according to the applied AI approaches. AI permits the processing of large quantities of information, data, and images stored in RT oncology information systems, a process that is not manageable for individuals or groups. AI allows the iterative application of complex tasks in large datasets (e.g., delineating normal tissues or finding optimal planning solutions) and might support the entire community working in the various sectors of RT, as summarized in this overview. AI-based tools are now on the roadmap for RT and have been applied to the entire workflow, mainly for segmentation, the generation of synthetic images, and outcome prediction. Several concerns were raised, including the need for harmonization while overcoming ethical, legal, and skill barriers.
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spelling doaj.art-a7f89ce32d33447b9d52b77e784b327a2023-11-30T22:52:43ZengMDPI AGApplied Sciences2076-34172022-03-01127322310.3390/app12073223Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and BeyondMiriam Santoro0Silvia Strolin1Giulia Paolani2Giuseppe Della Gala3Alessandro Bartoloni4Cinzia Giacometti5Ilario Ammendolia6Alessio Giuseppe Morganti7Lidia Strigari8Department of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyIstituto Nazionale di Fisica Nucleare (INFN) Sezione di Roma 1, 00185 Roma, ItalyDepartment of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Medical Physics, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyIn recent decades, artificial intelligence (AI) tools have been applied in many medical fields, opening the possibility of finding novel solutions for managing very complex and multifactorial problems, such as those commonly encountered in radiotherapy (RT). We conducted a PubMed and Scopus search to identify the AI application field in RT limited to the last four years. In total, 1824 original papers were identified, and 921 were analyzed by considering the phase of the RT workflow according to the applied AI approaches. AI permits the processing of large quantities of information, data, and images stored in RT oncology information systems, a process that is not manageable for individuals or groups. AI allows the iterative application of complex tasks in large datasets (e.g., delineating normal tissues or finding optimal planning solutions) and might support the entire community working in the various sectors of RT, as summarized in this overview. AI-based tools are now on the roadmap for RT and have been applied to the entire workflow, mainly for segmentation, the generation of synthetic images, and outcome prediction. Several concerns were raised, including the need for harmonization while overcoming ethical, legal, and skill barriers.https://www.mdpi.com/2076-3417/12/7/3223artificial intelligenceradiotherapyworkflowmachine learningdeep learningiterative optimization
spellingShingle Miriam Santoro
Silvia Strolin
Giulia Paolani
Giuseppe Della Gala
Alessandro Bartoloni
Cinzia Giacometti
Ilario Ammendolia
Alessio Giuseppe Morganti
Lidia Strigari
Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and Beyond
Applied Sciences
artificial intelligence
radiotherapy
workflow
machine learning
deep learning
iterative optimization
title Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and Beyond
title_full Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and Beyond
title_fullStr Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and Beyond
title_full_unstemmed Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and Beyond
title_short Recent Applications of Artificial Intelligence in Radiotherapy: Where We Are and Beyond
title_sort recent applications of artificial intelligence in radiotherapy where we are and beyond
topic artificial intelligence
radiotherapy
workflow
machine learning
deep learning
iterative optimization
url https://www.mdpi.com/2076-3417/12/7/3223
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