Impact of cyclic changes in pharmacokinetics and absorbed dose in pediatric neuroblastoma patients receiving [177Lu]Lu-DOTATATE

Impact of cyclic changes in pharmacokinetics and absorbed dose in pediatric neuroblastoma patients receiving [177Lu]Lu-DOTATATE

Abstract Purpose Recent reports personalizing the administered activity (AA) of each cycle of peptide receptor radionuclide therapy based on the predicted absorbed dose (AD) to the kidneys (dose-limiting organ) have been promising. Assuming identical renal pharmacokinetics for each cycle is pragmati...

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Bibliographic Details
Main Authors: Javian C. Malcolm, Nadia Falzone, Jennifer E. Gains, Matthew D. Aldridge, David Mirando, Boon Q. Lee, Mark N. Gaze, Katherine A. Vallis
Format: Article
Language:English
Published: SpringerOpen 2022-03-01
Series:EJNMMI Physics
Subjects:
[177Lu]Lu-DOTATATE
Dosimetry
Inter-cyclic changes
Pharmacokinetics
Peptide receptor radionuclide therapy
Neuroblastoma
Online Access:https://doi.org/10.1186/s40658-022-00436-4

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