IgA nephropathy associated with thalassemia: a case report
Abstract Background Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies have identified the renal effects of thalassemia syndrome. Chronic hypoxi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-020-01844-3 |
| _version_ | 1818408575012175872 |
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| author | Jun Ni Caifeng Zhu Xiaoqiu Ni Jiazhen Yin |
| author_facet | Jun Ni Caifeng Zhu Xiaoqiu Ni Jiazhen Yin |
| author_sort | Jun Ni |
| collection | DOAJ |
| description | Abstract Background Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies have identified the renal effects of thalassemia syndrome. Chronic hypoxia, long-term anemia, iron overload, and iron chelators are the major causes of renal tubular dysfunction and glomerular filtration abnormalities, while glomerulonephritis is not considered a major cause of abnormal urinalysis. Case presentation We report a case of a 38-year-old female patient with immunoglobulin A (IgA) nephropathy accompanied by anemia who was misdiagnosed initially, but was diagnosed with alpha-thalassemia after gene tests. We administered a combination of oral prednisolone, leflunomide, and angiotensin receptor blockers as well as folic acid and mecobalamin. During the follow-up, her proteinuria was significantly reduced, and her anemia was improved. Conclusions The possibility of occurrence of thalassemia should be considered in IgA nephropathy complicated with refractory anemia, especially in high-incidence areas of the disease. |
| first_indexed | 2024-12-14T09:45:54Z |
| format | Article |
| id | doaj.art-a7f95a775b1a4c7e94f24ccfdf343ade |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-14T09:45:54Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-a7f95a775b1a4c7e94f24ccfdf343ade2022-12-21T23:07:38ZengBMCBMC Nephrology1471-23692020-05-012111310.1186/s12882-020-01844-3IgA nephropathy associated with thalassemia: a case reportJun Ni0Caifeng Zhu1Xiaoqiu Ni2Jiazhen Yin3The Department of Nephrology (Key laboratory of management of kidney disease in Zhejiang province), Hangzhou Hospital of Traditional Chinese MedicineThe Department of Nephrology (Key laboratory of management of kidney disease in Zhejiang province), Hangzhou Hospital of Traditional Chinese MedicineZhejiang Chinese Medical UniversityThe Department of Nephrology (Key laboratory of management of kidney disease in Zhejiang province), Hangzhou Hospital of Traditional Chinese MedicineAbstract Background Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies have identified the renal effects of thalassemia syndrome. Chronic hypoxia, long-term anemia, iron overload, and iron chelators are the major causes of renal tubular dysfunction and glomerular filtration abnormalities, while glomerulonephritis is not considered a major cause of abnormal urinalysis. Case presentation We report a case of a 38-year-old female patient with immunoglobulin A (IgA) nephropathy accompanied by anemia who was misdiagnosed initially, but was diagnosed with alpha-thalassemia after gene tests. We administered a combination of oral prednisolone, leflunomide, and angiotensin receptor blockers as well as folic acid and mecobalamin. During the follow-up, her proteinuria was significantly reduced, and her anemia was improved. Conclusions The possibility of occurrence of thalassemia should be considered in IgA nephropathy complicated with refractory anemia, especially in high-incidence areas of the disease.http://link.springer.com/article/10.1186/s12882-020-01844-3α-ThalassemiaIgA nephropathyRenal complications |
| spellingShingle | Jun Ni Caifeng Zhu Xiaoqiu Ni Jiazhen Yin IgA nephropathy associated with thalassemia: a case report BMC Nephrology α-Thalassemia IgA nephropathy Renal complications |
| title | IgA nephropathy associated with thalassemia: a case report |
| title_full | IgA nephropathy associated with thalassemia: a case report |
| title_fullStr | IgA nephropathy associated with thalassemia: a case report |
| title_full_unstemmed | IgA nephropathy associated with thalassemia: a case report |
| title_short | IgA nephropathy associated with thalassemia: a case report |
| title_sort | iga nephropathy associated with thalassemia a case report |
| topic | α-Thalassemia IgA nephropathy Renal complications |
| url | http://link.springer.com/article/10.1186/s12882-020-01844-3 |
| work_keys_str_mv | AT junni iganephropathyassociatedwiththalassemiaacasereport AT caifengzhu iganephropathyassociatedwiththalassemiaacasereport AT xiaoqiuni iganephropathyassociatedwiththalassemiaacasereport AT jiazhenyin iganephropathyassociatedwiththalassemiaacasereport |