Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy

Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy

Background In mammals, muscle contraction is controlled by a family of 10 sarcomeric myosin motors. The expression of one of its members, MYH7b, is regulated by alternative splicing, and while the protein is restricted to specialized muscles such as extraocular muscles or muscle spindles, RNA that c...

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Bibliographic Details
Main Authors: Angela K. Peter, Alberto C. Rossi, Massimo Buvoli, Christopher D. Ozeroff, Claudia Crocini, Amy R. Perry, Ada E. Buvoli, Lindsey A. Lee, Leslie A. Leinwand
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac dysfunction
cardiac myocyte
MYH7b
myosin heavy chain
transgenic mice
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.013318

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