Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications
Objective: Treatment with antiseizure medications (ASMs) for more than 6 months requires monitoring of side effects, one of which is a decreased level of serum vitamin D. This study aimed to compare the influence of therapies with one versus multiple ASMs on 25-hydroxy vitamin D (25-OHD) levels amon...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Epilepsy & Behavior Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589986423000382 |
| _version_ | 1797400882551193600 |
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| author | Prastiya Indra Gunawan Nur Rochmah Muhammad Faizi |
| author_facet | Prastiya Indra Gunawan Nur Rochmah Muhammad Faizi |
| author_sort | Prastiya Indra Gunawan |
| collection | DOAJ |
| description | Objective: Treatment with antiseizure medications (ASMs) for more than 6 months requires monitoring of side effects, one of which is a decreased level of serum vitamin D. This study aimed to compare the influence of therapies with one versus multiple ASMs on 25-hydroxy vitamin D (25-OHD) levels among children with epilepsy. Methods: Our cross-sectional comparative study was conducted in the Paediatric Neurology Clinic at Soetomo Academic Hospital. Epileptic children aged 2–18 years who had been using ASMs for at least 6 months were enrolled and grouped according to whether they had been taking single or multiple ASMs. The mean 25-OHD levels of both groups were compared using a Welch t-test (95% confidence interval). Results: Among the 60 children enrolled, vitamin D deficiency was identified in 13% of children taking a single ASM and in 53% of ones taking multiple ASMs; mean 25-OHD levels were 26.6 (SD 5.29) ng/mL and 20.2 (SD 4.25) ng/mL, respectively. There was a significant difference between the groups (p = 0.001). Conclusions: Patients taking single and multiple ASMs have lower 25-OHD levels than expected for their age, with those taking multiple ASMs having the lowest 25-OHD levels. |
| first_indexed | 2024-03-09T02:02:01Z |
| format | Article |
| id | doaj.art-a7f9dbb3a1ec4648abde2ef2253ea94f |
| institution | Directory Open Access Journal |
| issn | 2589-9864 |
| language | English |
| last_indexed | 2024-03-09T02:02:01Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy & Behavior Reports |
| spelling | doaj.art-a7f9dbb3a1ec4648abde2ef2253ea94f2023-12-08T04:45:50ZengElsevierEpilepsy & Behavior Reports2589-98642023-01-0124100620Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medicationsPrastiya Indra Gunawan0Nur Rochmah1Muhammad Faizi2Pediatric Neurology Division, Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr Soetomo General Academic Hospital, Surabaya, Indonesia; Corresponding author.Pediatric Endocrinology Division, Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr Soetomo General Academic Hospital, Surabaya, IndonesiaPediatric Endocrinology Division, Department of Child Health, Faculty of Medicine Universitas Airlangga/Dr Soetomo General Academic Hospital, Surabaya, IndonesiaObjective: Treatment with antiseizure medications (ASMs) for more than 6 months requires monitoring of side effects, one of which is a decreased level of serum vitamin D. This study aimed to compare the influence of therapies with one versus multiple ASMs on 25-hydroxy vitamin D (25-OHD) levels among children with epilepsy. Methods: Our cross-sectional comparative study was conducted in the Paediatric Neurology Clinic at Soetomo Academic Hospital. Epileptic children aged 2–18 years who had been using ASMs for at least 6 months were enrolled and grouped according to whether they had been taking single or multiple ASMs. The mean 25-OHD levels of both groups were compared using a Welch t-test (95% confidence interval). Results: Among the 60 children enrolled, vitamin D deficiency was identified in 13% of children taking a single ASM and in 53% of ones taking multiple ASMs; mean 25-OHD levels were 26.6 (SD 5.29) ng/mL and 20.2 (SD 4.25) ng/mL, respectively. There was a significant difference between the groups (p = 0.001). Conclusions: Patients taking single and multiple ASMs have lower 25-OHD levels than expected for their age, with those taking multiple ASMs having the lowest 25-OHD levels.http://www.sciencedirect.com/science/article/pii/S2589986423000382Antiseizure medicationDiseaseEpilepsy25-Hydroxy vitamin D |
| spellingShingle | Prastiya Indra Gunawan Nur Rochmah Muhammad Faizi Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications Epilepsy & Behavior Reports Antiseizure medication Disease Epilepsy 25-Hydroxy vitamin D |
| title | Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications |
| title_full | Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications |
| title_fullStr | Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications |
| title_full_unstemmed | Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications |
| title_short | Comparison of 25-hydroxy vitamin D serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications |
| title_sort | comparison of 25 hydroxy vitamin d serum levels among children with epilepsy in therapy with single versus multiple antiseizure medications |
| topic | Antiseizure medication Disease Epilepsy 25-Hydroxy vitamin D |
| url | http://www.sciencedirect.com/science/article/pii/S2589986423000382 |
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