Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons
Despite mounting evidence that the mammalian retina is exceptionally reliant on proper NAD+ homeostasis for health and function, the specific roles of subcellular NAD+ pools in retinal development, maintenance, and disease remain obscure. Here, we show that deletion of the nuclear-localized NAD+ syn...
Main Authors: | David Sokolov, Emily R Sechrest, Yekai Wang, Connor Nevin, Jianhai Du, Saravanan Kolandaivelu |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/71185 |
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