Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity
The purpose of the research is to test the efficacy of triclafascid and two solid dispersion complex preparations based on the triclabendazole substance against fasciolosis in cattle and sheep. Materials and methods. Complex preparations of triclabendazole (TCB) formulations: Succinic Acid (SA): Pol...
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| Format: | Article |
| Language: | Russian |
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Federal Scientific Centre VIEV
2023-10-01
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| Series: | Российский паразитологический журнал |
| Subjects: | |
| Online Access: | https://vniigis.elpub.ru/jour/article/view/1061 |
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| author | M. B. Musaev M. S. Khalikov A. Z. Dzhamalova M. M. Ilyin S. S. Khalikov |
| author_facet | M. B. Musaev M. S. Khalikov A. Z. Dzhamalova M. M. Ilyin S. S. Khalikov |
| author_sort | M. B. Musaev |
| collection | DOAJ |
| description | The purpose of the research is to test the efficacy of triclafascid and two solid dispersion complex preparations based on the triclabendazole substance against fasciolosis in cattle and sheep. Materials and methods. Complex preparations of triclabendazole (TCB) formulations: Succinic Acid (SA): Polyvinylpyrrolidone (PVP) (1: 1 : 8) and TCB: SA: Arabinogalactan (AG) (1: 1 : 8) were obtained by combined solid-stategrinding of the components in a fiber drum on an LE-101 ball mill at a roll rotation speed of 60 rpm with a process module of 1: 17 for 1 to 6 hours with sampling for analysis (HPLC) for changes in the TCB solubility. A comparative test of the efficacy of triclafascid and new solid dispersions (SD) of TCB complexes with SA against fascioliasis of sheep and cattle was conducted in the North-Eastern Federal District of the Caucasus in March-April 2023. To determine the Fasciola infection rate in animals, fecal samples were individually taken and examined by the Fülleborn methods using saturated aqueous NaCL solution and sequential washing. The drug efficacy was recorded at 25-30 days after deworming in analogy with "critical test". The results were statistically processed by the Student-Fisher method using Microsoft Excel 2007. Results and discussion. The resulting TCB and SA complexes with polymers had an increased solubility (up to 59–70 times) that depended on the polymer nature. The efficacy of new TCB dosage forms against fascioliasis in sheep at a dose of 1.5 mg/kg, i.e. 0.5 mg/kg less than the therapeutic dose as compared with oral triclafascid was 90.0 and 100%, respectively, and 85.7% in cattle at a dose of 2.0 mg/kg for the active substance. |
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| id | doaj.art-a7fb621e18f64bdfb56b20f52ed8136d |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2024-04-25T02:04:17Z |
| publishDate | 2023-10-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj.art-a7fb621e18f64bdfb56b20f52ed8136d2024-03-07T14:34:32ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432023-10-0117340641210.31016/1998-8435-2023-17-3-406-412764Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activityM. B. Musaev0M. S. Khalikov1A. Z. Dzhamalova2M. M. Ilyin3S. S. Khalikov4All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV” (VNIIP – FSC VIEV)All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV” (VNIIP – FSC VIEV)Complex Scientific Research Institute named after Kh. I. Ibragimov of the RASFederal State Budgetary Institution of Science Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of SciencesFederal State Budgetary Institution of Science Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of SciencesThe purpose of the research is to test the efficacy of triclafascid and two solid dispersion complex preparations based on the triclabendazole substance against fasciolosis in cattle and sheep. Materials and methods. Complex preparations of triclabendazole (TCB) formulations: Succinic Acid (SA): Polyvinylpyrrolidone (PVP) (1: 1 : 8) and TCB: SA: Arabinogalactan (AG) (1: 1 : 8) were obtained by combined solid-stategrinding of the components in a fiber drum on an LE-101 ball mill at a roll rotation speed of 60 rpm with a process module of 1: 17 for 1 to 6 hours with sampling for analysis (HPLC) for changes in the TCB solubility. A comparative test of the efficacy of triclafascid and new solid dispersions (SD) of TCB complexes with SA against fascioliasis of sheep and cattle was conducted in the North-Eastern Federal District of the Caucasus in March-April 2023. To determine the Fasciola infection rate in animals, fecal samples were individually taken and examined by the Fülleborn methods using saturated aqueous NaCL solution and sequential washing. The drug efficacy was recorded at 25-30 days after deworming in analogy with "critical test". The results were statistically processed by the Student-Fisher method using Microsoft Excel 2007. Results and discussion. The resulting TCB and SA complexes with polymers had an increased solubility (up to 59–70 times) that depended on the polymer nature. The efficacy of new TCB dosage forms against fascioliasis in sheep at a dose of 1.5 mg/kg, i.e. 0.5 mg/kg less than the therapeutic dose as compared with oral triclafascid was 90.0 and 100%, respectively, and 85.7% in cattle at a dose of 2.0 mg/kg for the active substance.https://vniigis.elpub.ru/jour/article/view/1061triclabendazolesuccinic acidpolyvinylpyrrolidonearabinogalactanmechanochemistrysolid dispersionsolubilityefficacysheepcattle |
| spellingShingle | M. B. Musaev M. S. Khalikov A. Z. Dzhamalova M. M. Ilyin S. S. Khalikov Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity Российский паразитологический журнал triclabendazole succinic acid polyvinylpyrrolidone arabinogalactan mechanochemistry solid dispersion solubility efficacy sheep cattle |
| title | Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity |
| title_full | Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity |
| title_fullStr | Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity |
| title_full_unstemmed | Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity |
| title_short | Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity |
| title_sort | solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity |
| topic | triclabendazole succinic acid polyvinylpyrrolidone arabinogalactan mechanochemistry solid dispersion solubility efficacy sheep cattle |
| url | https://vniigis.elpub.ru/jour/article/view/1061 |
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