Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial Organisms
Jennifer Corwin-Buell, Denise Callahan, Deborah McGrath, Kimberly Millard, Gary Mosehauer, Nitasha R Phatak Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USACorrespondence: Nitasha R Phatak, Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA, Tel +1 585-413-6397, Email Nit...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | Clinical Ophthalmology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/biocidal-efficacies-of-contact-lens-disinfecting-solutions-against-int-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797325389565001728 |
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| author | Corwin-Buell J Callahan D McGrath D Millard K Mosehauer G Phatak NR |
| author_facet | Corwin-Buell J Callahan D McGrath D Millard K Mosehauer G Phatak NR |
| author_sort | Corwin-Buell J |
| collection | DOAJ |
| description | Jennifer Corwin-Buell, Denise Callahan, Deborah McGrath, Kimberly Millard, Gary Mosehauer, Nitasha R Phatak Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USACorrespondence: Nitasha R Phatak, Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA, Tel +1 585-413-6397, Email Nitasha.Phatak@bausch.comPurpose: This study was conducted to evaluate and compare the in vitro disinfection efficacies of six commercial lens cleaning and disinfecting products for planned replacement soft contact lenses.Methods: Disinfection efficacies of five multi-purpose solutions (MPSs) and one hydrogen peroxide solution (HPS) as control were evaluated in the presence of organic soil according to the International Organization for Standardization (ISO, Geneva, Switzerland) ISO 14729 stand-alone test protocol. The five specified compendial organisms, three bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens) and two fungi (Candida albicans and Fusarium solani) were incubated with each solution under standard conditions, after which microbes were recovered and quantified.Results: Each of the solutions evaluated met or exceeded the standard’s primary criteria (3-log reduction of bacteria and 1-log reduction of fungi) after incubation for the manufacturer-recommended soaking time, except for COMPLETE MPS, which achieved only 0.4 ± 0.1 average log reduction for C. albicans. However, differences in efficacy between the solutions were noted. Average log reduction across all microbes for Biotrue Hydration Plus (4.6 ± 0.1) was comparable to that for CLEAR CARE PLUS HPS (4.3 ± 0.1) and greater than those for OPTI-FREE puremoist (3.6 ± 0.1), OPTI-FREE Replenish (4.0 ± 0.2), ACUVUE RevitaLens (3.9 ± 0.03), and COMPLETE MPS (3.6 ± 0.1). Biotrue Hydration Plus was especially effective at reducing the population of C. albicans (4.2 ± 0.7-log reduction).Conclusion: Products marketed for planned replacement soft CL disinfection generally meet the ISO 14729 standard’s primary criteria for reducing populations of compendial organisms, with larger differences between solutions noted with C. albicans.Keywords: multi-purpose solution, MPS, hydrogen peroxide solution, HPS, disinfection, myristamidopropyl dimethylamine, MAPD, polyhexamethylene biguanide, PHMB, ISO 14729 |
| first_indexed | 2024-03-08T06:08:47Z |
| format | Article |
| id | doaj.art-a7fd9c4c8f4c451180e75793023da886 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-03-08T06:08:47Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-a7fd9c4c8f4c451180e75793023da8862024-02-04T17:43:33ZengDove Medical PressClinical Ophthalmology1177-54832024-02-01Volume 1833734590225Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial OrganismsCorwin-Buell JCallahan DMcGrath DMillard KMosehauer GPhatak NRJennifer Corwin-Buell, Denise Callahan, Deborah McGrath, Kimberly Millard, Gary Mosehauer, Nitasha R Phatak Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USACorrespondence: Nitasha R Phatak, Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA, Tel +1 585-413-6397, Email Nitasha.Phatak@bausch.comPurpose: This study was conducted to evaluate and compare the in vitro disinfection efficacies of six commercial lens cleaning and disinfecting products for planned replacement soft contact lenses.Methods: Disinfection efficacies of five multi-purpose solutions (MPSs) and one hydrogen peroxide solution (HPS) as control were evaluated in the presence of organic soil according to the International Organization for Standardization (ISO, Geneva, Switzerland) ISO 14729 stand-alone test protocol. The five specified compendial organisms, three bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Serratia marcescens) and two fungi (Candida albicans and Fusarium solani) were incubated with each solution under standard conditions, after which microbes were recovered and quantified.Results: Each of the solutions evaluated met or exceeded the standard’s primary criteria (3-log reduction of bacteria and 1-log reduction of fungi) after incubation for the manufacturer-recommended soaking time, except for COMPLETE MPS, which achieved only 0.4 ± 0.1 average log reduction for C. albicans. However, differences in efficacy between the solutions were noted. Average log reduction across all microbes for Biotrue Hydration Plus (4.6 ± 0.1) was comparable to that for CLEAR CARE PLUS HPS (4.3 ± 0.1) and greater than those for OPTI-FREE puremoist (3.6 ± 0.1), OPTI-FREE Replenish (4.0 ± 0.2), ACUVUE RevitaLens (3.9 ± 0.03), and COMPLETE MPS (3.6 ± 0.1). Biotrue Hydration Plus was especially effective at reducing the population of C. albicans (4.2 ± 0.7-log reduction).Conclusion: Products marketed for planned replacement soft CL disinfection generally meet the ISO 14729 standard’s primary criteria for reducing populations of compendial organisms, with larger differences between solutions noted with C. albicans.Keywords: multi-purpose solution, MPS, hydrogen peroxide solution, HPS, disinfection, myristamidopropyl dimethylamine, MAPD, polyhexamethylene biguanide, PHMB, ISO 14729https://www.dovepress.com/biocidal-efficacies-of-contact-lens-disinfecting-solutions-against-int-peer-reviewed-fulltext-article-OPTHkeywords: multi-purpose solutionmpshydrogen peroxide solutionhpsdisinfectionmyristamidopropyl dimethylaminemapdpolyhexamethylene biguanidephmbiso 14729. |
| spellingShingle | Corwin-Buell J Callahan D McGrath D Millard K Mosehauer G Phatak NR Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial Organisms Clinical Ophthalmology keywords: multi-purpose solution mps hydrogen peroxide solution hps disinfection myristamidopropyl dimethylamine mapd polyhexamethylene biguanide phmb iso 14729. |
| title | Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial Organisms |
| title_full | Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial Organisms |
| title_fullStr | Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial Organisms |
| title_full_unstemmed | Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial Organisms |
| title_short | Biocidal Efficacies of Contact Lens Disinfecting Solutions Against International Organization for Standardization (ISO) Compendial Organisms |
| title_sort | biocidal efficacies of contact lens disinfecting solutions against international organization for standardization iso compendial organisms |
| topic | keywords: multi-purpose solution mps hydrogen peroxide solution hps disinfection myristamidopropyl dimethylamine mapd polyhexamethylene biguanide phmb iso 14729. |
| url | https://www.dovepress.com/biocidal-efficacies-of-contact-lens-disinfecting-solutions-against-int-peer-reviewed-fulltext-article-OPTH |
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