Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells
Carbon nanotubes are highly versatile materials; new applications using them are continuously being developed. Special attention is being dedicated to the possible use of multiwall carbon nanotubes in biomaterials contacting with bone. This study describes the response of murine macrophage-like Raw...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Lubricants |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4442/3/3/597 |
| _version_ | 1798034602307092480 |
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| author | Nayeli Camacho Stephen W. Stafford Kristine M. Garza Raquel Suro Kristina I. Barron |
| author_facet | Nayeli Camacho Stephen W. Stafford Kristine M. Garza Raquel Suro Kristina I. Barron |
| author_sort | Nayeli Camacho |
| collection | DOAJ |
| description | Carbon nanotubes are highly versatile materials; new applications using them are continuously being developed. Special attention is being dedicated to the possible use of multiwall carbon nanotubes in biomaterials contacting with bone. This study describes the response of murine macrophage-like Raw 264.7 cells after two and six days of culture in contact with artificially generated particles from both, ultra-high molecular weight polyethylene polymer and the composite (multiwall carbon nanotubes and ultra-high molecular weight polyethylene). This novel composite has superior wear behavior, having thus the potential to reduce the number of revision knee arthroplasty surgeries required by wear failure of tibial articulating component and diminish particle-induced osteolysis. The results of an in vitro study of viability, and interleukin-6 and tumor necrosis factor-alpha production suggest good cytocompatibility, similar to that of conventional ultra-high molecular weight polyethylene. |
| first_indexed | 2024-04-11T20:46:36Z |
| format | Article |
| id | doaj.art-a7ff2e9773564f0cad55880b296af0d2 |
| institution | Directory Open Access Journal |
| issn | 2075-4442 |
| language | English |
| last_indexed | 2024-04-11T20:46:36Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Lubricants |
| spelling | doaj.art-a7ff2e9773564f0cad55880b296af0d22022-12-22T04:04:00ZengMDPI AGLubricants2075-44422015-07-013359761010.3390/lubricants3030597lubricants3030597Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like CellsNayeli Camacho0Stephen W. Stafford1Kristine M. Garza2Raquel Suro3Kristina I. Barron4Metallurgical and Materials Engineering Department, University of Texas at El Paso, El Paso, TX 79968, USAMetallurgical and Materials Engineering Department, University of Texas at El Paso, El Paso, TX 79968, USABorder Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, USABiological Science Department, University of Texas at El Paso, El Paso, TX 79968, USABiological Science Department, University of Texas at El Paso, El Paso, TX 79968, USACarbon nanotubes are highly versatile materials; new applications using them are continuously being developed. Special attention is being dedicated to the possible use of multiwall carbon nanotubes in biomaterials contacting with bone. This study describes the response of murine macrophage-like Raw 264.7 cells after two and six days of culture in contact with artificially generated particles from both, ultra-high molecular weight polyethylene polymer and the composite (multiwall carbon nanotubes and ultra-high molecular weight polyethylene). This novel composite has superior wear behavior, having thus the potential to reduce the number of revision knee arthroplasty surgeries required by wear failure of tibial articulating component and diminish particle-induced osteolysis. The results of an in vitro study of viability, and interleukin-6 and tumor necrosis factor-alpha production suggest good cytocompatibility, similar to that of conventional ultra-high molecular weight polyethylene.http://www.mdpi.com/2075-4442/3/3/597in vitro macrophages responseknee replacementmultiwall carbon nanotubesultra-high molecular weight polyethylenewear debris cytotoxicity |
| spellingShingle | Nayeli Camacho Stephen W. Stafford Kristine M. Garza Raquel Suro Kristina I. Barron Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells Lubricants in vitro macrophages response knee replacement multiwall carbon nanotubes ultra-high molecular weight polyethylene wear debris cytotoxicity |
| title | Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells |
| title_full | Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells |
| title_fullStr | Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells |
| title_full_unstemmed | Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells |
| title_short | Ultra-High Molecular Weight Polyethylene Reinforced with Multiwall Carbon Nanotubes: In Vitro Biocompatibility Study Using Macrophage-Like Cells |
| title_sort | ultra high molecular weight polyethylene reinforced with multiwall carbon nanotubes in vitro biocompatibility study using macrophage like cells |
| topic | in vitro macrophages response knee replacement multiwall carbon nanotubes ultra-high molecular weight polyethylene wear debris cytotoxicity |
| url | http://www.mdpi.com/2075-4442/3/3/597 |
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