Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities
AbstractHigh-risk human papillomaviruses (HPVs) 16 and 18 are responsible for more than 70% of cervical cancers and majority of other HPV-associated cancers world-wide. Current treatments for these cancers have limited efficacy, which in turn has resulted in disease recurrence and po...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2023-02-01
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| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad020 |
| _version_ | 1797788961827979264 |
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| author | Quincy P Collins Michael J Grunsted Dahiana Arcila Yi Xiong Mojgan Padash Barmchi |
| author_facet | Quincy P Collins Michael J Grunsted Dahiana Arcila Yi Xiong Mojgan Padash Barmchi |
| author_sort | Quincy P Collins |
| collection | DOAJ |
| description |
AbstractHigh-risk human papillomaviruses (HPVs) 16 and 18 are responsible for more than 70% of cervical cancers and majority of other HPV-associated cancers world-wide. Current treatments for these cancers have limited efficacy, which in turn has resulted in disease recurrence and poor survival rates in advanced disease stages. Hence, there is a significant need for development of novel molecularly-targeted therapeutics. This can only be achieved through improved understanding of disease mechanism. Recently, we developed a Drosophila |
| first_indexed | 2024-03-13T01:43:00Z |
| format | Article |
| id | doaj.art-a8006480ff5147c581fd924f5c30c614 |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-03-13T01:43:00Z |
| publishDate | 2023-02-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-a8006480ff5147c581fd924f5c30c6142023-07-03T11:12:58ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362023-02-0113410.1093/g3journal/jkad020Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalitiesQuincy P Collins0Michael J Grunsted1Dahiana Arcila2Yi Xiong3Mojgan Padash Barmchi4Department of Biology, University of Oklahoma, Norman, OK 73019, USADepartment of Biology, University of Oklahoma, Norman, OK 73019, USADepartment of Biology, University of Oklahoma, Norman, OK 73019, USADepartment of Microbiology and Plant Biology, University of Oklahoma, Norman, OK 73019, USADepartment of Biology, University of Oklahoma, Norman, OK 73019, USA AbstractHigh-risk human papillomaviruses (HPVs) 16 and 18 are responsible for more than 70% of cervical cancers and majority of other HPV-associated cancers world-wide. Current treatments for these cancers have limited efficacy, which in turn has resulted in disease recurrence and poor survival rates in advanced disease stages. Hence, there is a significant need for development of novel molecularly-targeted therapeutics. This can only be achieved through improved understanding of disease mechanism. Recently, we developed a Drosophilahttps://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad020 |
| spellingShingle | Quincy P Collins Michael J Grunsted Dahiana Arcila Yi Xiong Mojgan Padash Barmchi Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities G3: Genes, Genomes, Genetics |
| title | Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities |
| title_full | Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities |
| title_fullStr | Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities |
| title_full_unstemmed | Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities |
| title_short | Transcriptomic analysis provides insight into the mechanism of IKKβ-mediated suppression of HPV18E6-induced cellular abnormalities |
| title_sort | transcriptomic analysis provides insight into the mechanism of ikkβ mediated suppression of hpv18e6 induced cellular abnormalities |
| url | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad020 |
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