Inhibition of Melanization by Kojic Acid Promotes Cell Wall Disruption of the Human Pathogenic Fungus <i>Fonsecaea</i> sp.

Inhibition of Melanization by Kojic Acid Promotes Cell Wall Disruption of the Human Pathogenic Fungus <i>Fonsecaea</i> sp.

Chromoblastomycosis (CBM) is a chronic human subcutaneous mycosis caused by various aetiologic agents. CBM does not have an established treatment but may be managed using antifungal agents, surgical removal of the lesions, or cryotherapy. Kojic acid (KA), a known tyrosinase inhibitor with a variety...

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Bibliographic Details
Main Authors: Jorge Augusto Leão Pereira, Lienne Silveira de Moraes, Chubert Bernardo Castro de Sena, José Luiz Martins do Nascimento, Ana Paula D. Rodrigues, Silvia Helena Marques da Silva, Edilene O. Silva
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pathogens
Subjects:
chromoblastomycosis
<i>Fonsecaea</i> sp.
kojic acid
melanin
cell wall
Online Access:https://www.mdpi.com/2076-0817/11/8/925

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