Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing
In clinical practice, the utilization of antibiotics is still the main approach for the treatment of wound contamination, which lacks the ability to accelerate wound healing and arises the global concern of antimicrobial resistance. Plenty of alternative methods have been explored in recent years du...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1158007/full |
| _version_ | 1811160825656770560 |
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| author | Yanping Feng Yanping Feng Yanping Feng Mingzhen Wu Mingzhen Wu Haidong Zhang He Xu Huili Li Huili Li Dongmin Chen Dongmin Chen Hongyi Jiang Jiang Chang Jiang Chang Jiang Chang Zhihong Dong Chen Yang Chen Yang |
| author_facet | Yanping Feng Yanping Feng Yanping Feng Mingzhen Wu Mingzhen Wu Haidong Zhang He Xu Huili Li Huili Li Dongmin Chen Dongmin Chen Hongyi Jiang Jiang Chang Jiang Chang Jiang Chang Zhihong Dong Chen Yang Chen Yang |
| author_sort | Yanping Feng |
| collection | DOAJ |
| description | In clinical practice, the utilization of antibiotics is still the main approach for the treatment of wound contamination, which lacks the ability to accelerate wound healing and arises the global concern of antimicrobial resistance. Plenty of alternative methods have been explored in recent years due to the fast development of material science. Here, CuO/SiO2 nanowires (CuSi NWs) with good near-infrared (NIR) photothermal conversion ability are synthesized by a one-step hydrothermal method. The as-prepared CuSi NWs possess excellent antibacterial ability against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), which could be enhanced by the assistance of mild photothermal therapy (PTT). Moreover, CuSi NWs at suitable concentrations can promote proliferation, migration, and angiogenic gene expression of human umbilical vein endothelial cells (HUVECs), exhibiting a remarkable pro-vascularization ability. The in vivo mouse infect model further proves that the CuSi NWs might be a good candidate for the treatment of infected wounds as the high antibacterial efficiency and accelerated wound healing is obtained. |
| first_indexed | 2024-04-10T06:04:09Z |
| format | Article |
| id | doaj.art-a801468944194f79bb1f92c63c5f9b09 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-10T06:04:09Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a801468944194f79bb1f92c63c5f9b092023-03-03T04:36:21ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-03-011110.3389/fbioe.2023.11580071158007Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healingYanping Feng0Yanping Feng1Yanping Feng2Mingzhen Wu3Mingzhen Wu4Haidong Zhang5He Xu6Huili Li7Huili Li8Dongmin Chen9Dongmin Chen10Hongyi Jiang11Jiang Chang12Jiang Chang13Jiang Chang14Zhihong Dong15Chen Yang16Chen Yang17College of Mechanical Engineering, Chengdu University, Chengdu, Sichuan, ChinaJoint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaCollege of Chemistry and Materials Sciences, Shanghai Normal University, Shanghai, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, ChinaCollege of Chemistry and Materials Sciences, Shanghai Normal University, Shanghai, ChinaJoint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaJoint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaJoint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaCollege of Chemistry and Materials Sciences, Shanghai Normal University, Shanghai, ChinaCollege of Mechanical Engineering, Chengdu University, Chengdu, Sichuan, ChinaJoint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaZhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, ChinaIn clinical practice, the utilization of antibiotics is still the main approach for the treatment of wound contamination, which lacks the ability to accelerate wound healing and arises the global concern of antimicrobial resistance. Plenty of alternative methods have been explored in recent years due to the fast development of material science. Here, CuO/SiO2 nanowires (CuSi NWs) with good near-infrared (NIR) photothermal conversion ability are synthesized by a one-step hydrothermal method. The as-prepared CuSi NWs possess excellent antibacterial ability against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), which could be enhanced by the assistance of mild photothermal therapy (PTT). Moreover, CuSi NWs at suitable concentrations can promote proliferation, migration, and angiogenic gene expression of human umbilical vein endothelial cells (HUVECs), exhibiting a remarkable pro-vascularization ability. The in vivo mouse infect model further proves that the CuSi NWs might be a good candidate for the treatment of infected wounds as the high antibacterial efficiency and accelerated wound healing is obtained.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1158007/fullnanowireanti-bacteriaangiogenesisinfected woundphotothermal therapy |
| spellingShingle | Yanping Feng Yanping Feng Yanping Feng Mingzhen Wu Mingzhen Wu Haidong Zhang He Xu Huili Li Huili Li Dongmin Chen Dongmin Chen Hongyi Jiang Jiang Chang Jiang Chang Jiang Chang Zhihong Dong Chen Yang Chen Yang Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing Frontiers in Bioengineering and Biotechnology nanowire anti-bacteria angiogenesis infected wound photothermal therapy |
| title | Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing |
| title_full | Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing |
| title_fullStr | Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing |
| title_full_unstemmed | Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing |
| title_short | Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing |
| title_sort | mild temperature photothermal assisted cusi nanowires for promoting infected wound healing |
| topic | nanowire anti-bacteria angiogenesis infected wound photothermal therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1158007/full |
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