Seizure-induced overexpression of NPY induces epileptic tolerance in a mouse model of spontaneous recurrent seizures

Seizure-induced overexpression of NPY induces epileptic tolerance in a mouse model of spontaneous recurrent seizures

Epileptic seizures result in pronounced over-expression of neuropeptide Y (NPY). In vivo and in vitro studies revealed that NPY exerts potent anticonvulsive actions through presynaptic Y2 receptors by suppressing glutamate release from principal neurons. We now investigated whether seizure-induced o...

Full description

Bibliographic Details
Main Authors: Meinrad Drexel, Günther Sperk
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuropeptide Y
somatostatin
CB1 receptor
subiculum
hippocampus
ischemic tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.974784/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.974784/full

Similar Items