Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or Obesity
(1) Background: Adolescents present as a high-risk group for a range of adverse physical health outcomes during the pandemic, including sleep and C-reactive protein (CRP) levels. As adolescents with overweight or obesity (OWOB) present as an even higher risk group, the present study assessed relatio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/12/1833 |
| _version_ | 1797381611155619840 |
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| author | Lindsay M. Stager Casie H. Morgan Caroline S. Watson Aaron D. Fobian |
| author_facet | Lindsay M. Stager Casie H. Morgan Caroline S. Watson Aaron D. Fobian |
| author_sort | Lindsay M. Stager |
| collection | DOAJ |
| description | (1) Background: Adolescents present as a high-risk group for a range of adverse physical health outcomes during the pandemic, including sleep and C-reactive protein (CRP) levels. As adolescents with overweight or obesity (OWOB) present as an even higher risk group, the present study assessed relationships between sleep and CRP levels before and during COVID-19 in adolescents with OWOB. (2) Methods: Fourteen adolescents with OWOB participated in a pre-COVID1, pre-COVID2, and during-COVID-19 lab visit, measuring sleep and CRP levels. The sample size was limited by the number of participants who provided data before COVID-19 and who were enrolled in virtual school during the recruitment phase. However, our power analyses indicated needing a minimum of 10 participants to achieve adequate power. Pre-COVID1, pre-COVID2, and during-COVID-19 normative expected CRP levels were calculated based on age, sex, race, and body mass index percentile-matched data. Analyses compared pre-COVID1 and pre-COVID2 sleep with during-COVID-19 sleep, during-COVID-19 sleep and during-COVID-19 CRP levels, during-COVID-19 CRP levels with normative expected during-COVID-19 CRP levels, change in CRP levels from pre-COVID1 and pre-COVID2 to during-COVID-19 with normative expected CRP levels during those time periods, and change in CRP levels before COVID-19 with change in CRP levels during COVID-19. (3) Results. During COVID-19, participants experienced decreased sleep efficiency (<i>p</i> = 0.001), later wake time (<i>p</i> < 0.001), longer time in bed (<i>p</i> = 0.021), and onset latency (<i>p</i> = 0.004), compared to pre-COVID1, and decreased sleep efficiency (<i>p</i> = 0.002), longer onset latency (<i>p</i> = 0.006), and later wake time (<i>p</i> < 0.001) and bedtime (<i>p</i> = 0.016) compared with pre-COVID2. During-COVID-19 CRP levels were positively correlated with during-COVID-19 wake times (<i>p</i> = 0.01) and times in bed (<i>p</i> = 0.008). During-COVID-19 CRP levels were greater than normative expected CRP levels (<i>p</i> < 0.001). CRP levels increased more from pre-COVID1 and pre-COVID2 to during-COVID-19 than normative expected changes in CRP levels (<i>p</i> < 0.003). Changes in CRP levels before and during COVID-19 were not significantly different. (4) Conclusions. These findings highlight the consequential effects of COVID-19, including impairments in sleep, on adolescents with OWOB. CRP levels increased more (~5 mg/L) during COVID-19 than normative expected change. |
| first_indexed | 2024-03-08T20:53:55Z |
| format | Article |
| id | doaj.art-a8033e20fb6141bdaaa42afe002ce3e6 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-08T20:53:55Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-a8033e20fb6141bdaaa42afe002ce3e62023-12-22T14:00:13ZengMDPI AGChildren2227-90672023-11-011012183310.3390/children10121833Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or ObesityLindsay M. Stager0Casie H. Morgan1Caroline S. Watson2Aaron D. Fobian3Department of Psychology, University of Alabama at Birmingham, 1300 University Blvd, Birmingham, AL 35233, USADepartment of Psychology, University of Alabama at Birmingham, 1300 University Blvd, Birmingham, AL 35233, USADepartment of Psychology, University of Alabama at Birmingham, 1300 University Blvd, Birmingham, AL 35233, USADepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue South, Birmingham, AL 35233, USA(1) Background: Adolescents present as a high-risk group for a range of adverse physical health outcomes during the pandemic, including sleep and C-reactive protein (CRP) levels. As adolescents with overweight or obesity (OWOB) present as an even higher risk group, the present study assessed relationships between sleep and CRP levels before and during COVID-19 in adolescents with OWOB. (2) Methods: Fourteen adolescents with OWOB participated in a pre-COVID1, pre-COVID2, and during-COVID-19 lab visit, measuring sleep and CRP levels. The sample size was limited by the number of participants who provided data before COVID-19 and who were enrolled in virtual school during the recruitment phase. However, our power analyses indicated needing a minimum of 10 participants to achieve adequate power. Pre-COVID1, pre-COVID2, and during-COVID-19 normative expected CRP levels were calculated based on age, sex, race, and body mass index percentile-matched data. Analyses compared pre-COVID1 and pre-COVID2 sleep with during-COVID-19 sleep, during-COVID-19 sleep and during-COVID-19 CRP levels, during-COVID-19 CRP levels with normative expected during-COVID-19 CRP levels, change in CRP levels from pre-COVID1 and pre-COVID2 to during-COVID-19 with normative expected CRP levels during those time periods, and change in CRP levels before COVID-19 with change in CRP levels during COVID-19. (3) Results. During COVID-19, participants experienced decreased sleep efficiency (<i>p</i> = 0.001), later wake time (<i>p</i> < 0.001), longer time in bed (<i>p</i> = 0.021), and onset latency (<i>p</i> = 0.004), compared to pre-COVID1, and decreased sleep efficiency (<i>p</i> = 0.002), longer onset latency (<i>p</i> = 0.006), and later wake time (<i>p</i> < 0.001) and bedtime (<i>p</i> = 0.016) compared with pre-COVID2. During-COVID-19 CRP levels were positively correlated with during-COVID-19 wake times (<i>p</i> = 0.01) and times in bed (<i>p</i> = 0.008). During-COVID-19 CRP levels were greater than normative expected CRP levels (<i>p</i> < 0.001). CRP levels increased more from pre-COVID1 and pre-COVID2 to during-COVID-19 than normative expected changes in CRP levels (<i>p</i> < 0.003). Changes in CRP levels before and during COVID-19 were not significantly different. (4) Conclusions. These findings highlight the consequential effects of COVID-19, including impairments in sleep, on adolescents with OWOB. CRP levels increased more (~5 mg/L) during COVID-19 than normative expected change.https://www.mdpi.com/2227-9067/10/12/1833COVID-19adolescentsleepinflammationobesity |
| spellingShingle | Lindsay M. Stager Casie H. Morgan Caroline S. Watson Aaron D. Fobian Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or Obesity Children COVID-19 adolescent sleep inflammation obesity |
| title | Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or Obesity |
| title_full | Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or Obesity |
| title_fullStr | Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or Obesity |
| title_full_unstemmed | Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or Obesity |
| title_short | Sleep and Inflammation during COVID-19 Virtual Learning in Adolescents with Overweight or Obesity |
| title_sort | sleep and inflammation during covid 19 virtual learning in adolescents with overweight or obesity |
| topic | COVID-19 adolescent sleep inflammation obesity |
| url | https://www.mdpi.com/2227-9067/10/12/1833 |
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