Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells
The present study has investigated how mulberrofuran G affects prolifera-tion, invasion, and migration of the lung adenocarcinoma and squamous cell carcinoma. Four different concentrations of mulberrofuran G (1, 5, 10, and 100 μmol/L) were used to simulate human lung adenocarcinoma cells (A549 cells...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2021-12-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://ojs3306.nepjol.info/index.php/BJP/article/view/55198 |
| _version_ | 1818945455667544064 |
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| author | Hai-Yuan-Bo Guo Xiao-Xiao Liu Xiao-Yong Zhu Zhe Yu |
| author_facet | Hai-Yuan-Bo Guo Xiao-Xiao Liu Xiao-Yong Zhu Zhe Yu |
| author_sort | Hai-Yuan-Bo Guo |
| collection | DOAJ |
| description | The present study has investigated how mulberrofuran G affects prolifera-tion, invasion, and migration of the lung adenocarcinoma and squamous cell carcinoma. Four different concentrations of mulberrofuran G (1, 5, 10, and 100 μmol/L) were used to simulate human lung adenocarcinoma cells (A549 cells) and squamous-cell carcinoma (NCI-H226 cells). The results showed that mulberrofuran G significantly inhibited the proliferation, invasion, and migration of both A549 and NCI-H226 cells, with a dose-effect relationship. The IC50 inhibited the growth of A549 cells and NCI-H226 cells by mulberrofuran G were 22.5 and 30.6 μmol/L, respectively. It strengthened the expression of CDK4 and MMP9 but significantly weakened the expression of p27 in both A549 cells and NCI-H226 cells. Furthermore, the expression of p-JAK2 and p-STAT3 was significantly down-regulated in drug treatments. In conclusion, mulberrofuran G could inhibit proliferation, migration, and invasion of lung cancer cells via inactivating JAK2/STAT3 signaling. |
| first_indexed | 2024-12-20T07:59:23Z |
| format | Article |
| id | doaj.art-a8050e5be2c9467ab25036c11971ecc9 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-20T07:59:23Z |
| publishDate | 2021-12-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-a8050e5be2c9467ab25036c11971ecc92022-12-21T19:47:34ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882021-12-01164Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cellsHai-Yuan-Bo Guo0Xiao-Xiao Liu1Xiao-Yong Zhu2Zhe Yu3Department of Medical Oncology, Pinghu Second People’s Hospital, Pinghu City, Zhejiang Province 314200, China.Department of Medical Oncology, Xinchang People's Hospital of Zhejiang Province, Shaoxing City, Zhejiang Province 312500, China.Department of Second Ward of Medical Oncology, Zhuji People's Hospital of Zhejiang Province, Shaoxing City, Zhejiang Province 311800, China.Department of Respiratory Medicine, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo City, Zhejiang Province 315099, China.The present study has investigated how mulberrofuran G affects prolifera-tion, invasion, and migration of the lung adenocarcinoma and squamous cell carcinoma. Four different concentrations of mulberrofuran G (1, 5, 10, and 100 μmol/L) were used to simulate human lung adenocarcinoma cells (A549 cells) and squamous-cell carcinoma (NCI-H226 cells). The results showed that mulberrofuran G significantly inhibited the proliferation, invasion, and migration of both A549 and NCI-H226 cells, with a dose-effect relationship. The IC50 inhibited the growth of A549 cells and NCI-H226 cells by mulberrofuran G were 22.5 and 30.6 μmol/L, respectively. It strengthened the expression of CDK4 and MMP9 but significantly weakened the expression of p27 in both A549 cells and NCI-H226 cells. Furthermore, the expression of p-JAK2 and p-STAT3 was significantly down-regulated in drug treatments. In conclusion, mulberrofuran G could inhibit proliferation, migration, and invasion of lung cancer cells via inactivating JAK2/STAT3 signaling.https://ojs3306.nepjol.info/index.php/BJP/article/view/55198Mulberrofuran Glung adenocarcinoma cellslung squamous cell carcinoma cellsproliferationmigrationJAK2/STAT3 signaling |
| spellingShingle | Hai-Yuan-Bo Guo Xiao-Xiao Liu Xiao-Yong Zhu Zhe Yu Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells Bangladesh Journal of Pharmacology Mulberrofuran G lung adenocarcinoma cells lung squamous cell carcinoma cells proliferation migration JAK2/STAT3 signaling |
| title | Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells |
| title_full | Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells |
| title_fullStr | Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells |
| title_full_unstemmed | Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells |
| title_short | Mulberrofuran G inhibits proliferation and migration by inactivating JAK2/STAT3 signaling in lung cancer cells |
| title_sort | mulberrofuran g inhibits proliferation and migration by inactivating jak2 stat3 signaling in lung cancer cells |
| topic | Mulberrofuran G lung adenocarcinoma cells lung squamous cell carcinoma cells proliferation migration JAK2/STAT3 signaling |
| url | https://ojs3306.nepjol.info/index.php/BJP/article/view/55198 |
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