Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols
The synthesis of some novel alkyl/aryl substituted tertiary alcohols was accomplished in two steps. The synthetic route involves preparation of Grignard reagents by treating alkyl/aryl bromides with magnesium turnings in dry ether. Then substituted chalcones were reacted with the Grignard reagents t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/12/10337/ |
| _version_ | 1818211606922788864 |
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| author | Rafiuzzaman SaeedulHaq Muhammad Baseer Farzana Latif Ansari Zaman Ashraf |
| author_facet | Rafiuzzaman SaeedulHaq Muhammad Baseer Farzana Latif Ansari Zaman Ashraf |
| author_sort | Rafiuzzaman SaeedulHaq |
| collection | DOAJ |
| description | The synthesis of some novel alkyl/aryl substituted tertiary alcohols was accomplished in two steps. The synthetic route involves preparation of Grignard reagents by treating alkyl/aryl bromides with magnesium turnings in dry ether. Then substituted chalcones were reacted with the Grignard reagents to afford alkyl/aryl substituted tertiary alcohols 1-10. The structures of the synthesized compounds were assigned on the basis of FT-IR, 1H-NMR, 13C-NMR and mass spectroscopic data. The in vivo anti-inflammatory activity of the synthesized compounds was evaluated using the carrageenan-induced hind paw edema method and was compared with that of ibuprofen. Some of the newly synthesized compounds showed promising anti-inflammatory activity. The tertiary alcohols 1-10 were also screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and for antifungal activity against Aspergillus Flavus, Aspergillus Niger and Aspergillus pterus. Tertiary alcohols 1-10 were found to exhibit good to excellent antimicrobial activities compared to levofloxacin and fluconazole used as standard drugs. |
| first_indexed | 2024-12-12T05:35:11Z |
| format | Article |
| id | doaj.art-a80542b546ff4784bb494788332830ec |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T05:35:11Z |
| publishDate | 2011-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-a80542b546ff4784bb494788332830ec2022-12-22T00:36:10ZengMDPI AGMolecules1420-30492011-12-011612103371034610.3390/molecules161210337Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary AlcoholsRafiuzzaman SaeedulHaqMuhammad BaseerFarzana Latif AnsariZaman AshrafThe synthesis of some novel alkyl/aryl substituted tertiary alcohols was accomplished in two steps. The synthetic route involves preparation of Grignard reagents by treating alkyl/aryl bromides with magnesium turnings in dry ether. Then substituted chalcones were reacted with the Grignard reagents to afford alkyl/aryl substituted tertiary alcohols 1-10. The structures of the synthesized compounds were assigned on the basis of FT-IR, 1H-NMR, 13C-NMR and mass spectroscopic data. The in vivo anti-inflammatory activity of the synthesized compounds was evaluated using the carrageenan-induced hind paw edema method and was compared with that of ibuprofen. Some of the newly synthesized compounds showed promising anti-inflammatory activity. The tertiary alcohols 1-10 were also screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and for antifungal activity against Aspergillus Flavus, Aspergillus Niger and Aspergillus pterus. Tertiary alcohols 1-10 were found to exhibit good to excellent antimicrobial activities compared to levofloxacin and fluconazole used as standard drugs.http://www.mdpi.com/1420-3049/16/12/10337/tertiary alcoholsanti-inflammatory activityantibacterial activityantifungal activity |
| spellingShingle | Rafiuzzaman SaeedulHaq Muhammad Baseer Farzana Latif Ansari Zaman Ashraf Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols Molecules tertiary alcohols anti-inflammatory activity antibacterial activity antifungal activity |
| title | Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols |
| title_full | Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols |
| title_fullStr | Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols |
| title_full_unstemmed | Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols |
| title_short | Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols |
| title_sort | synthesis characterization anti inflammatory and in vitro antimicrobial activity of some novel alkyl aryl substituted tertiary alcohols |
| topic | tertiary alcohols anti-inflammatory activity antibacterial activity antifungal activity |
| url | http://www.mdpi.com/1420-3049/16/12/10337/ |
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