Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats
The present study aimed to evaluate the effect of Terminalia pallida fruit ethanolic extract (TpFE) on lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase (PON) in isoproterenol (ISO)-induced myocardial infarcted rats. PON is an excellent serum antioxidant enzyme which involves in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Saudi Journal of Biological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X17302760 |
| _version_ | 1798045058784559104 |
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| author | Althaf Hussain Shaik Nayab Rasool Shaik Abdul Kareem Mohammed Suliman Yousef Al Omar Altaf Mohammad Talal Abdulaziz Mohaya Lakshmi Devi Kodidhela |
| author_facet | Althaf Hussain Shaik Nayab Rasool Shaik Abdul Kareem Mohammed Suliman Yousef Al Omar Altaf Mohammad Talal Abdulaziz Mohaya Lakshmi Devi Kodidhela |
| author_sort | Althaf Hussain Shaik |
| collection | DOAJ |
| description | The present study aimed to evaluate the effect of Terminalia pallida fruit ethanolic extract (TpFE) on lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase (PON) in isoproterenol (ISO)-induced myocardial infarcted rats. PON is an excellent serum antioxidant enzyme which involves in the protection of low density lipoprotein cholesterol (LDL-C) from the process of oxidation for the prevention of cardiovascular diseases. ISO caused a significant increase in the concentration of total cholesterol, triglycerides, LDL-C, very low density lipoprotein cholesterol and lipid peroxidation whereas significant decrease in the concentration of high density lipoprotein cholesterol. ISO administration also significantly decreased the activities of lecithin cholesterol acyl transferase, PON and lipoprotein lipase whereas significantly increased the activity of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. Oral pretreatment of TpFE at doses 100, 300 and 500 mg/kg body weight (bw) and gallic acid (15 mg/kg bw) for 30 days challenged with concurrent injection of ISO (85 mg/kg bw) on 29th and 30th day significantly attenuated these alterations and restored the levels of lipids, lipoproteins and the activities of lipid metabolizing enzymes. Also TpFE significantly elevated the serum antioxidant enzyme PON. This is the first report revealed that pretreatment with TPFE ameliorated lipid metabolic marker enzymes and increased the antioxidant PON in ISO treated male albino Wistar rats. Keywords: Terminalia pallida fruit, Gallic acid, Isoproterenol, Lipid metabolism marker enzymes, Paraoxonase, Myocardial infarction |
| first_indexed | 2024-04-11T23:14:34Z |
| format | Article |
| id | doaj.art-a8054ad2cf004944ad6557cbac2c4a24 |
| institution | Directory Open Access Journal |
| issn | 1319-562X |
| language | English |
| last_indexed | 2024-04-11T23:14:34Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Journal of Biological Sciences |
| spelling | doaj.art-a8054ad2cf004944ad6557cbac2c4a242022-12-22T03:57:41ZengElsevierSaudi Journal of Biological Sciences1319-562X2018-03-01253431436Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted ratsAlthaf Hussain Shaik0Nayab Rasool Shaik1Abdul Kareem Mohammed2Suliman Yousef Al Omar3Altaf Mohammad4Talal Abdulaziz Mohaya5Lakshmi Devi Kodidhela6Central Laboratory, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; Corresponding author at: Central Laboratory, Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.Department of Biochemistry, National Post Graduate College, Nandyal, Andhra Pradesh, IndiaDepartment of Biochemistry, School of Sciences, Indira Gandhi National Open University, Saket, New Delhi, IndiaDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi ArabiaCentral Laboratory, College of Science, King Saud University, Riyadh, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi ArabiaDepartment of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, IndiaThe present study aimed to evaluate the effect of Terminalia pallida fruit ethanolic extract (TpFE) on lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase (PON) in isoproterenol (ISO)-induced myocardial infarcted rats. PON is an excellent serum antioxidant enzyme which involves in the protection of low density lipoprotein cholesterol (LDL-C) from the process of oxidation for the prevention of cardiovascular diseases. ISO caused a significant increase in the concentration of total cholesterol, triglycerides, LDL-C, very low density lipoprotein cholesterol and lipid peroxidation whereas significant decrease in the concentration of high density lipoprotein cholesterol. ISO administration also significantly decreased the activities of lecithin cholesterol acyl transferase, PON and lipoprotein lipase whereas significantly increased the activity of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. Oral pretreatment of TpFE at doses 100, 300 and 500 mg/kg body weight (bw) and gallic acid (15 mg/kg bw) for 30 days challenged with concurrent injection of ISO (85 mg/kg bw) on 29th and 30th day significantly attenuated these alterations and restored the levels of lipids, lipoproteins and the activities of lipid metabolizing enzymes. Also TpFE significantly elevated the serum antioxidant enzyme PON. This is the first report revealed that pretreatment with TPFE ameliorated lipid metabolic marker enzymes and increased the antioxidant PON in ISO treated male albino Wistar rats. Keywords: Terminalia pallida fruit, Gallic acid, Isoproterenol, Lipid metabolism marker enzymes, Paraoxonase, Myocardial infarctionhttp://www.sciencedirect.com/science/article/pii/S1319562X17302760 |
| spellingShingle | Althaf Hussain Shaik Nayab Rasool Shaik Abdul Kareem Mohammed Suliman Yousef Al Omar Altaf Mohammad Talal Abdulaziz Mohaya Lakshmi Devi Kodidhela Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats Saudi Journal of Biological Sciences |
| title | Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats |
| title_full | Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats |
| title_fullStr | Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats |
| title_full_unstemmed | Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats |
| title_short | Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats |
| title_sort | terminalia pallida fruit ethanolic extract ameliorates lipids lipoproteins lipid metabolism marker enzymes and paraoxonase in isoproterenol induced myocardial infarcted rats |
| url | http://www.sciencedirect.com/science/article/pii/S1319562X17302760 |
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