The Effect of Hypoxia and Metformin on Fatty Acid Uptake, Storage, and Oxidation in L6 Differentiated Myotubes

The Effect of Hypoxia and Metformin on Fatty Acid Uptake, Storage, and Oxidation in L6 Differentiated Myotubes

Metabolic impairments associated with obstructive sleep apnea syndrome (OSA) are linked to tissue hypoxia, however, the explanatory molecular and endocrine mechanisms remain unknown. Using gas-permeable cultureware, we studied the chronic effects of mild and severe hypoxia on free fatty acid (FFA) u...

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Bibliographic Details
Main Authors: Martina Musutova, Moustafa Elkalaf, Natalie Klubickova, Michal Koc, Stanislav Povysil, Jan Rambousek, Beatriz Volckaert, Frantisek Duska, Minh Duc Trinh, Martin Kalous, Jan Trnka, Kamila Balusikova, Jan Kovar, Jan Polak
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Endocrinology
Subjects:
hypoxia
myotubes
free fatty acids
FFA oxidation
FFA uptake
metformin
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00616/full

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