A Comparative Clinical Evaluation of Once Daily Versus Alternate Day Application of Topical Clobetasol Propionate Cream in Psoriasis
ABSTRACT Background: Corticosteroids are extremely useful in the treatment of inflammatory skin disorders. Topical steroid applications are the most effective treatment for all types of psoriasis. Aims: To compare the efficacy of once daily versus alternate day application of topical steroid clo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2681/26-%204904_E(C)_PF1(M)_F(P)_PF1(PM)_PFA(P)_OLF_PF1(R)P.pdf |
| Summary: | ABSTRACT
Background: Corticosteroids are extremely useful in the treatment of inflammatory skin disorders. Topical steroid applications
are the most effective treatment for all types of psoriasis.
Aims: To compare the efficacy of once daily versus alternate
day application of topical steroid clobetasol propionate 0.05%
(Tenovate cream®) in patients who have mild to moderate
plaque psoriasis.
Settings and Design: This study was conducted on 89 patients
of plaque psoriasis, who attended the skin OPD in our hospital.
Methods and Material: The patients who had a mild to moderate severity of plaque psoriasis were selected. Those patients
who required systemic corticosteroids, those who were already
undergoing any psoriasis treatment, those who had any other
debilitating illness and pregnant and lactating women were excluded from the study. Eighty nine patients were enrolled for the
study after taking written informed consent from them and they
were randomly allocated into two groups. Two patients dropped
out, one in each group and 1 of group 2 was prescribed systemic corticosteroids.
Group 1- once daily application (n= 44)
Group 2- alternate day application (n= 42)
An objective scoring was done on the basis of the PSI (Psoriasis
Severity Index) score, which was graded from 0-4. Follow ups
were done in the 2nd, 4th and 6th weeks.
Statistical Analysis: It was done by the Student’s ‘t’ test and
ANOVA.
Results and Conclusions: The results showed that there was
equal improvement in both the groups in the 2nd week, since
the p-value was not significant (P> 0.05), but in the 4th and 6th
weeks, there was less improvement in the alternate day group
(P< 0.05). An intra group comparison indicated that clobetasol was effective both in the once daily and the alternate day
groups, but clinical and symptomatic improvement occurred
more quickly in the once daily group after 6 weeks of assessment. Thus, it can be concluded that the alternate day application of the topical steroid clobetasol propionate cream is as
effective as the once daily application in the initial 2 weeks, but
by 6 weeks, its efficacy decreases. Therefore, initially, we can
advocate a less frequent application of potent topical steroids
but for the complete remission of the disease, the application
frequency should be once daily. |
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| ISSN: | 2249-782X 0973-709X |