The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney disease
IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease characterized by fibroinflammatory tumor-like masses that show the peculiar morphological features of storiform fibrosis, lymphoplasmacytic infiltrates rich in IgG4 positive plasma cells and obliterans phlebitis. The disease affect...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2021-10-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-10-e45.pdf |
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| author | Francesco Fortarezza Michele Rossini Maria Grazia Fiore Domenico Piscitelli Loreto Gesualdo Leonardo Resta Roberta Rossi |
| author_facet | Francesco Fortarezza Michele Rossini Maria Grazia Fiore Domenico Piscitelli Loreto Gesualdo Leonardo Resta Roberta Rossi |
| author_sort | Francesco Fortarezza |
| collection | DOAJ |
| description | IgG4-related disease (IgG4-RD) is a systemic immune-mediated disease characterized by fibroinflammatory tumor-like masses that show the peculiar morphological features of storiform fibrosis, lymphoplasmacytic infiltrates rich in IgG4 positive plasma cells and obliterans phlebitis. The disease affects virtually any organ or apparatus and is often associated with increased serum IgG4 levels. Many previously described conditions (e.g. autoimmune pancreatitis, Mikulicz’s syndrome, Küttner’s tumor, and Riedel’s thyroiditis) are now classified to be part of IgG4-RD with the characteristic clinic, serologic and pathologic features. The kidney represents an important target-organ of the disease, mainly as tubulointerstitial nephritis (TIN). Nevertheless, some cases of glomerular disease, especially membranous glomerulonephritis (MNG), have been described in IgG4-related TIN. We report a case of IgG4-related kidney disease in which the two pathological patterns, TIN and MNG, were observed simultaneously in the same biopsy. |
| first_indexed | 2024-04-09T12:58:25Z |
| format | Article |
| id | doaj.art-a8094375dd494969aa398f7b4ca31f8f |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:58:25Z |
| publishDate | 2021-10-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-a8094375dd494969aa398f7b4ca31f8f2023-05-13T11:06:16ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192021-10-01104e45e4510.34172/jnp.2021.45jnp-17132The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney diseaseFrancesco Fortarezza0Michele Rossini1Maria Grazia Fiore2Domenico Piscitelli3Loreto Gesualdo4Leonardo Resta5Roberta Rossi6Department of Emergency and Organ Transplantation, Pathology Division, Medical School, University of Bari, Bari, ItalyDepartment of Emergency and Organ Transplantation, Nephrology Division, Medical School, University of Bari, Bari, ItalyDepartment of Emergency and Organ Transplantation, Pathology Division, Medical School, University of Bari, Bari, ItalyDepartment of Emergency and Organ Transplantation, Pathology Division, Medical School, University of Bari, Bari, ItalyDepartment of Emergency and Organ Transplantation, Nephrology Division, Medical School, University of Bari, Bari, ItalyDepartment of Emergency and Organ Transplantation, Pathology Division, Medical School, University of Bari, Bari, ItalyDepartment of Emergency and Organ Transplantation, Pathology Division, Medical School, University of Bari, Bari, ItalyIgG4-related disease (IgG4-RD) is a systemic immune-mediated disease characterized by fibroinflammatory tumor-like masses that show the peculiar morphological features of storiform fibrosis, lymphoplasmacytic infiltrates rich in IgG4 positive plasma cells and obliterans phlebitis. The disease affects virtually any organ or apparatus and is often associated with increased serum IgG4 levels. Many previously described conditions (e.g. autoimmune pancreatitis, Mikulicz’s syndrome, Küttner’s tumor, and Riedel’s thyroiditis) are now classified to be part of IgG4-RD with the characteristic clinic, serologic and pathologic features. The kidney represents an important target-organ of the disease, mainly as tubulointerstitial nephritis (TIN). Nevertheless, some cases of glomerular disease, especially membranous glomerulonephritis (MNG), have been described in IgG4-related TIN. We report a case of IgG4-related kidney disease in which the two pathological patterns, TIN and MNG, were observed simultaneously in the same biopsy.https://nephropathol.com/PDF/jnp-10-e45.pdfigg4-related kidney diseasetubulointerstitial nephritismembranous glomerulonephritiskidney biopsy |
| spellingShingle | Francesco Fortarezza Michele Rossini Maria Grazia Fiore Domenico Piscitelli Loreto Gesualdo Leonardo Resta Roberta Rossi The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney disease Journal of Nephropathology igg4-related kidney disease tubulointerstitial nephritis membranous glomerulonephritis kidney biopsy |
| title | The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney disease |
| title_full | The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney disease |
| title_fullStr | The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney disease |
| title_full_unstemmed | The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney disease |
| title_short | The coexistence of membranous glomerulonephritis and its cause in the same biopsy: the two faces of IgG4-related kidney disease |
| title_sort | coexistence of membranous glomerulonephritis and its cause in the same biopsy the two faces of igg4 related kidney disease |
| topic | igg4-related kidney disease tubulointerstitial nephritis membranous glomerulonephritis kidney biopsy |
| url | https://nephropathol.com/PDF/jnp-10-e45.pdf |
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