Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular Procedures
<b>Introduction:</b> The use of 3D-printed aortic models for the creation of surgeon-modified endoprostheses represents a promising avenue in aortic surgery. By focusing on the potential impact of sterilization on model integrity and geometry, this report sheds light on the suitability o...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1309 |
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| author | Max Wilkat Julian Lommen Majeed Rana Norbert Kübler Tobias Wienemann Sönke Maximilian Braß Reinhold Thomas Ziegler Agnesa Mazrekaj Artis Knapsis Hubert Schelzig Markus Udo Wagenhäuser Amir Arnautovic |
| author_facet | Max Wilkat Julian Lommen Majeed Rana Norbert Kübler Tobias Wienemann Sönke Maximilian Braß Reinhold Thomas Ziegler Agnesa Mazrekaj Artis Knapsis Hubert Schelzig Markus Udo Wagenhäuser Amir Arnautovic |
| author_sort | Max Wilkat |
| collection | DOAJ |
| description | <b>Introduction:</b> The use of 3D-printed aortic models for the creation of surgeon-modified endoprostheses represents a promising avenue in aortic surgery. By focusing on the potential impact of sterilization on model integrity and geometry, this report sheds light on the suitability of these models for creating customized endoprostheses. The study presented here aimed to investigate the safety and viability of 3D-printed aortic models in the context of sterilization processes and subsequent remodeling. <b>Methods:</b> The study involved the fabrication of 3D-printed aortic models using patient-specific imaging data and established additive manufacturing techniques. Five identical aortic models of the same patient were printed. Two models were subjected to sterilization and two to disinfection using commonly employed methods, and one model remained untreated. The models were checked by in-house quality control for deformation (heat map analyses) after the sterilization and disinfection processes. Three models (sterilized, disinfected, and untreated) were sent for ex-house (Lufthansa Technik, AG, Materials Technologies and Central Laboratory Services, Hamburg, Germany) evaluation and subsequent quantification of possible structural changes using advanced imaging and measurement technologies (macroscopic and SEM/EDX examinations). After sterilization and disinfection, each aortic model underwent sterility checks. <b>Results:</b> Based on macroscopic and SEM/EDX examinations, distinct evidence of material alterations attributed to a treatment process, such as a cleaning procedure, was not identified on the three implants. Comparative material analyses conducted via the EDX technique yield consistent results for all three implants. Disinfected and sterilized models tested negative for common pathogens. <b>Conclusions:</b> The evaluation of 3D-printed aortic models’ safety after sterilization as well as their suitability for surgeon-modified endoprostheses is a critical step toward their clinical integration. By comprehensively assessing changes in model integrity and geometry after sterilization, this research has contributed to the broader understanding of the use of 3D-printed models for tailor-made endovascular solutions. As medical technologies continue to evolve, research endeavors such as this one can serve as a foundation for harnessing the full potential of 3D printing to advance patient-centered care in aortic surgery. |
| first_indexed | 2024-04-25T00:26:54Z |
| format | Article |
| id | doaj.art-a809859de60c4379b43632a2504cc436 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:54Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a809859de60c4379b43632a2504cc4362024-03-12T16:47:57ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135130910.3390/jcm13051309Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular ProceduresMax Wilkat0Julian Lommen1Majeed Rana2Norbert Kübler3Tobias Wienemann4Sönke Maximilian Braß5Reinhold Thomas Ziegler6Agnesa Mazrekaj7Artis Knapsis8Hubert Schelzig9Markus Udo Wagenhäuser10Amir Arnautovic11Department for Oral & Maxillofacial Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Oral & Maxillofacial Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Oral & Maxillofacial Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Oral & Maxillofacial Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyInstitute of Medical Microbiology and Hospital Hygiene, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, GermanyDepartment for Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, 40225 Düsseldorf, Germany<b>Introduction:</b> The use of 3D-printed aortic models for the creation of surgeon-modified endoprostheses represents a promising avenue in aortic surgery. By focusing on the potential impact of sterilization on model integrity and geometry, this report sheds light on the suitability of these models for creating customized endoprostheses. The study presented here aimed to investigate the safety and viability of 3D-printed aortic models in the context of sterilization processes and subsequent remodeling. <b>Methods:</b> The study involved the fabrication of 3D-printed aortic models using patient-specific imaging data and established additive manufacturing techniques. Five identical aortic models of the same patient were printed. Two models were subjected to sterilization and two to disinfection using commonly employed methods, and one model remained untreated. The models were checked by in-house quality control for deformation (heat map analyses) after the sterilization and disinfection processes. Three models (sterilized, disinfected, and untreated) were sent for ex-house (Lufthansa Technik, AG, Materials Technologies and Central Laboratory Services, Hamburg, Germany) evaluation and subsequent quantification of possible structural changes using advanced imaging and measurement technologies (macroscopic and SEM/EDX examinations). After sterilization and disinfection, each aortic model underwent sterility checks. <b>Results:</b> Based on macroscopic and SEM/EDX examinations, distinct evidence of material alterations attributed to a treatment process, such as a cleaning procedure, was not identified on the three implants. Comparative material analyses conducted via the EDX technique yield consistent results for all three implants. Disinfected and sterilized models tested negative for common pathogens. <b>Conclusions:</b> The evaluation of 3D-printed aortic models’ safety after sterilization as well as their suitability for surgeon-modified endoprostheses is a critical step toward their clinical integration. By comprehensively assessing changes in model integrity and geometry after sterilization, this research has contributed to the broader understanding of the use of 3D-printed models for tailor-made endovascular solutions. As medical technologies continue to evolve, research endeavors such as this one can serve as a foundation for harnessing the full potential of 3D printing to advance patient-centered care in aortic surgery.https://www.mdpi.com/2077-0383/13/5/1309patient-specific implantaortic reconstructionin-house 3D-printing |
| spellingShingle | Max Wilkat Julian Lommen Majeed Rana Norbert Kübler Tobias Wienemann Sönke Maximilian Braß Reinhold Thomas Ziegler Agnesa Mazrekaj Artis Knapsis Hubert Schelzig Markus Udo Wagenhäuser Amir Arnautovic Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular Procedures Journal of Clinical Medicine patient-specific implant aortic reconstruction in-house 3D-printing |
| title | Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular Procedures |
| title_full | Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular Procedures |
| title_fullStr | Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular Procedures |
| title_full_unstemmed | Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular Procedures |
| title_short | Accuracy and Sterilizability of In-House Printed Patient-Specific Aortic Model for Surgeon-Modified Stent Grafts—A Workflow Description for Emergency Aortic Endovascular Procedures |
| title_sort | accuracy and sterilizability of in house printed patient specific aortic model for surgeon modified stent grafts a workflow description for emergency aortic endovascular procedures |
| topic | patient-specific implant aortic reconstruction in-house 3D-printing |
| url | https://www.mdpi.com/2077-0383/13/5/1309 |
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