Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However, biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible...

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Bibliographic Details
Main Authors: Zhiqin Cao, Shaoyang Li, Jianming Lv, Hao Gao, Guodong Chen, Takayoshi Awakawa, Ikuro Abe, Xinsheng Yao, Dan Hu
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383518308062

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