Radiotherapy-induced ferroptosis for cancer treatment
Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical studies have demonstrated that the combination...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1216733/full |
| _version_ | 1797804477216980992 |
|---|---|
| author | Giovanni L. Beretta Nadia Zaffaroni |
| author_facet | Giovanni L. Beretta Nadia Zaffaroni |
| author_sort | Giovanni L. Beretta |
| collection | DOAJ |
| description | Ferroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical studies have demonstrated that the combination of ionizing radiation with small molecules or nano-systems is effective in combating cancer growth and overcoming drug or ionizing radiation resistance. Here, we briefly overview the mechanisms of ferroptosis and the cross-talk existing between the cellular pathways activated by ferroptosis and those induced by radiotherapy. Lastly, we discuss the recently reported combinational studies involving radiotherapy, small molecules as well as nano-systems and report the recent findings achieved in this field for the treatment of tumors. |
| first_indexed | 2024-03-13T05:37:46Z |
| format | Article |
| id | doaj.art-a80a0b47a98a47a784c16e50fd20592f |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-13T05:37:46Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-a80a0b47a98a47a784c16e50fd20592f2023-06-14T05:43:41ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-06-011010.3389/fmolb.2023.12167331216733Radiotherapy-induced ferroptosis for cancer treatmentGiovanni L. BerettaNadia ZaffaroniFerroptosis is a regulated cell death mechanism controlled by iron, amino acid and reactive oxygen species metabolisms, which is very relevant for cancer therapy. Radiotherapy-induced ferroptosis is critical for tumor suppression and several preclinical studies have demonstrated that the combination of ionizing radiation with small molecules or nano-systems is effective in combating cancer growth and overcoming drug or ionizing radiation resistance. Here, we briefly overview the mechanisms of ferroptosis and the cross-talk existing between the cellular pathways activated by ferroptosis and those induced by radiotherapy. Lastly, we discuss the recently reported combinational studies involving radiotherapy, small molecules as well as nano-systems and report the recent findings achieved in this field for the treatment of tumors.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1216733/fullferroptosisradiotherapyreactive oxygen speciesnanomedicinedrug combinationsgene signatures |
| spellingShingle | Giovanni L. Beretta Nadia Zaffaroni Radiotherapy-induced ferroptosis for cancer treatment Frontiers in Molecular Biosciences ferroptosis radiotherapy reactive oxygen species nanomedicine drug combinations gene signatures |
| title | Radiotherapy-induced ferroptosis for cancer treatment |
| title_full | Radiotherapy-induced ferroptosis for cancer treatment |
| title_fullStr | Radiotherapy-induced ferroptosis for cancer treatment |
| title_full_unstemmed | Radiotherapy-induced ferroptosis for cancer treatment |
| title_short | Radiotherapy-induced ferroptosis for cancer treatment |
| title_sort | radiotherapy induced ferroptosis for cancer treatment |
| topic | ferroptosis radiotherapy reactive oxygen species nanomedicine drug combinations gene signatures |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1216733/full |
| work_keys_str_mv | AT giovannilberetta radiotherapyinducedferroptosisforcancertreatment AT nadiazaffaroni radiotherapyinducedferroptosisforcancertreatment |