Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea
Abstract Single-tablet regimens (STRs) should be considered for patients with HIV/AIDS to increase medication compliance and improve clinical outcomes. This study compared variations in the prescription trends between STRs and multiple-tablet regimens (MTRs) for treatment-naïve patients with HIV/AID...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-06005-0 |
| _version_ | 1818330552247255040 |
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| author | Kyung Sun Oh Gi Hyeon Seo Hee Kyoung Choi Euna Han |
| author_facet | Kyung Sun Oh Gi Hyeon Seo Hee Kyoung Choi Euna Han |
| author_sort | Kyung Sun Oh |
| collection | DOAJ |
| description | Abstract Single-tablet regimens (STRs) should be considered for patients with HIV/AIDS to increase medication compliance and improve clinical outcomes. This study compared variations in the prescription trends between STRs and multiple-tablet regimens (MTRs) for treatment-naïve patients with HIV/AIDS after the approval of the new STRs, a proxy indicator for improvement in medication adherence. The medical and pharmacy claim data were retrospectively obtained from the Health Insurance Review and Assessment service, which contains basic information on the patients’ sociodemographic characteristics and treatment information for the entire Korean population. From 2013 to 2018, a total of 6737 patients with HIV/AIDS were included. Most patients were men (92.8%, n = 6251) and insured through the National Health Insurance (95.1%, n = 6410). The mean number of pills in their antiretroviral treatment regimens decreased from 2.8 ± 1.2 in 2013 to 1.2 ± 1.0 in 2018. After the first STR (EVG/c/TDF/FTC) was approved in 2014, prescription transitions from MTR to STR were observed among more than 38% of patients. In 2018, most treatment-naïve patients were prescribed STRs (91.2%). There was a time lag for STR prescription trends in non-metropolitan hospitals compared with those in metropolitan cities. Our data provide a valuable perspective for evaluating ART regimen prescription patterns on a national scale. |
| first_indexed | 2024-12-13T13:05:46Z |
| format | Article |
| id | doaj.art-a80a65f2ef2540239f8d455ed6b48e0e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T13:05:46Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a80a65f2ef2540239f8d455ed6b48e0e2022-12-21T23:44:50ZengNature PortfolioScientific Reports2045-23222022-02-011211810.1038/s41598-022-06005-0Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in KoreaKyung Sun Oh0Gi Hyeon Seo1Hee Kyoung Choi2Euna Han3College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei UniversityHealth Insurance Review and Assessment ServiceCollege of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei UniversityCollege of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei UniversityAbstract Single-tablet regimens (STRs) should be considered for patients with HIV/AIDS to increase medication compliance and improve clinical outcomes. This study compared variations in the prescription trends between STRs and multiple-tablet regimens (MTRs) for treatment-naïve patients with HIV/AIDS after the approval of the new STRs, a proxy indicator for improvement in medication adherence. The medical and pharmacy claim data were retrospectively obtained from the Health Insurance Review and Assessment service, which contains basic information on the patients’ sociodemographic characteristics and treatment information for the entire Korean population. From 2013 to 2018, a total of 6737 patients with HIV/AIDS were included. Most patients were men (92.8%, n = 6251) and insured through the National Health Insurance (95.1%, n = 6410). The mean number of pills in their antiretroviral treatment regimens decreased from 2.8 ± 1.2 in 2013 to 1.2 ± 1.0 in 2018. After the first STR (EVG/c/TDF/FTC) was approved in 2014, prescription transitions from MTR to STR were observed among more than 38% of patients. In 2018, most treatment-naïve patients were prescribed STRs (91.2%). There was a time lag for STR prescription trends in non-metropolitan hospitals compared with those in metropolitan cities. Our data provide a valuable perspective for evaluating ART regimen prescription patterns on a national scale.https://doi.org/10.1038/s41598-022-06005-0 |
| spellingShingle | Kyung Sun Oh Gi Hyeon Seo Hee Kyoung Choi Euna Han Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea Scientific Reports |
| title | Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea |
| title_full | Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea |
| title_fullStr | Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea |
| title_full_unstemmed | Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea |
| title_short | Effect of single tablet regimen on prescription trends for treatment-naïve patients with HIV/AIDS in Korea |
| title_sort | effect of single tablet regimen on prescription trends for treatment naive patients with hiv aids in korea |
| url | https://doi.org/10.1038/s41598-022-06005-0 |
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