Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation
Background. Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated. Objectives. To examine the risk factors in the development of CRF...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-03-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119303862 |
| _version_ | 1818608183715823616 |
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| author | Ip Stephen Trana Hussaini Aliya Daulat Nilufar Partovi Siegfried R. Erb Eric M. Yoshida Vladimir Marquez |
| author_facet | Ip Stephen Trana Hussaini Aliya Daulat Nilufar Partovi Siegfried R. Erb Eric M. Yoshida Vladimir Marquez |
| author_sort | Ip Stephen |
| collection | DOAJ |
| description | Background. Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated. Objectives. To examine the risk factors in the development of CRF in these patients.Material and methods. Retrospective case-cohort of liver transplant patients without baseline kidney dysfunction who developed chronic renal failure during their follow-up.Results. Of 370 patients, 254 met the inclusion criteria. 30% (76) of these patients had CRF of which 57% (43) were male. Age, estimated glomerular filtration rate (eGFR) at discharge, and HCV infection were found to be risk factors for CRF post-LT. The odds ratio of developing CRF was 1.4 (0.6-3.3) in males with HCV, 1.6 (0.7-3.9) in females without HCV and 4.4 (1.5-13.2) among females with HCV when compared to men without HCV.Conclusions. In this cohort of LT receipients of a major Canadian city, age, eGFR, and HCV infection were risk factors for CRF. Female gender and HCV increased this odds by a factor of more than 4. |
| first_indexed | 2024-12-16T14:38:36Z |
| format | Article |
| id | doaj.art-a80a83fb6e054364ac6c909492fc9103 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-16T14:38:36Z |
| publishDate | 2017-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-a80a83fb6e054364ac6c909492fc91032022-12-21T22:28:02ZengElsevierAnnals of Hepatology1665-26812017-03-01162230235Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver TransplantationIp Stephen0Trana Hussaini1Aliya Daulat2Nilufar Partovi3Siegfried R. Erb4Eric M. Yoshida5Vladimir Marquez6Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, CanadaFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, CanadaFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, CanadaFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, CanadaDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, CanadaDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, CanadaDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Correspondence and reprint request:Background. Chronic renal failure (CRF) is a significant cause of morbidity and mortality in post-liver transplantation (LT) recipients. The risk factors associated with the development of renal dysfunction are not clearly elucidated. Objectives. To examine the risk factors in the development of CRF in these patients.Material and methods. Retrospective case-cohort of liver transplant patients without baseline kidney dysfunction who developed chronic renal failure during their follow-up.Results. Of 370 patients, 254 met the inclusion criteria. 30% (76) of these patients had CRF of which 57% (43) were male. Age, estimated glomerular filtration rate (eGFR) at discharge, and HCV infection were found to be risk factors for CRF post-LT. The odds ratio of developing CRF was 1.4 (0.6-3.3) in males with HCV, 1.6 (0.7-3.9) in females without HCV and 4.4 (1.5-13.2) among females with HCV when compared to men without HCV.Conclusions. In this cohort of LT receipients of a major Canadian city, age, eGFR, and HCV infection were risk factors for CRF. Female gender and HCV increased this odds by a factor of more than 4.http://www.sciencedirect.com/science/article/pii/S1665268119303862Liver transplantKidney failureCalcineurin inhibitorsGenderPrognosis |
| spellingShingle | Ip Stephen Trana Hussaini Aliya Daulat Nilufar Partovi Siegfried R. Erb Eric M. Yoshida Vladimir Marquez Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation Annals of Hepatology Liver transplant Kidney failure Calcineurin inhibitors Gender Prognosis |
| title | Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation |
| title_full | Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation |
| title_fullStr | Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation |
| title_full_unstemmed | Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation |
| title_short | Interaction of Gender and Hepatitis C in Risk of Chronic Renal Failure After Liver Transplantation |
| title_sort | interaction of gender and hepatitis c in risk of chronic renal failure after liver transplantation |
| topic | Liver transplant Kidney failure Calcineurin inhibitors Gender Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119303862 |
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