Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strains
Invasive aspergillosis is the primary opportunistic invasive fungal infection described in neutropenic hematologic patients, caused by the angioinvasive pathogen Aspergillus fumigatus. The molecular mechanisms associated with A. fumigatus infection in the vascular endothelium are poorly understood....
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2016-12-01
|
| Series: | Data in Brief |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235234091630498X |
| _version_ | 1811285326772043776 |
|---|---|
| author | Gabriela Westerlund Peixoto Neves Nathália Curty Paula Helena Kubitschek-Barreira Thierry Fontaine Gustavo Henrique Martins Ferreira Souza Marcel Lyra Cunha Gustavo H. Goldman Anne Beauvais Jean-Paul Latgé Leila M. Lopes-Bezerra |
| author_facet | Gabriela Westerlund Peixoto Neves Nathália Curty Paula Helena Kubitschek-Barreira Thierry Fontaine Gustavo Henrique Martins Ferreira Souza Marcel Lyra Cunha Gustavo H. Goldman Anne Beauvais Jean-Paul Latgé Leila M. Lopes-Bezerra |
| author_sort | Gabriela Westerlund Peixoto Neves |
| collection | DOAJ |
| description | Invasive aspergillosis is the primary opportunistic invasive fungal infection described in neutropenic hematologic patients, caused by the angioinvasive pathogen Aspergillus fumigatus. The molecular mechanisms associated with A. fumigatus infection in the vascular endothelium are poorly understood. In this context, we used a high-throughput proteomic approach to unveil the proteins modulated in HUVECs after interaction with a wild type strain and the UGM1 mutant (Δugm1) of A. fumigatus. The proteomic analysis was also performed in HUVECs challenged with a galactosaminogalactan (GAG) purified from A. fumigatus cell wall. The dataset presented here correspond to all proteins identified that fit a 2-fold change criteria (log 2 ratio ≥ 1 or ≤ −1), disregarding the statistical validation cut off, in order to supplement the research article entitled “Modifications to the composition of the hyphal outer layer of Aspergillus fumigatus modulates the HUVEC proteins associated with inflammatory and stress responses” (G.W.P. Neves, N.A. Curty, P.H. Kubitschek-Barreira, T. Fontaine, G.H.M.F. Souza, M. Lyra Cunha, G.H. Goldman, A. Beauvais, J.P. Latgé, L.M. Lopes-Bezerra, 2016) [1]. The mass spectrometry proteomic data have been deposited in the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PRIDE: PXD002823. |
| first_indexed | 2024-04-13T02:42:20Z |
| format | Article |
| id | doaj.art-a80afe1a366f41d7ab566c1dffbf9919 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-13T02:42:20Z |
| publishDate | 2016-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-a80afe1a366f41d7ab566c1dffbf99192022-12-22T03:06:09ZengElsevierData in Brief2352-34092016-12-019C243110.1016/j.dib.2016.07.062Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strainsGabriela Westerlund Peixoto Neves0Nathália Curty1Paula Helena Kubitschek-Barreira2Thierry Fontaine3Gustavo Henrique Martins Ferreira Souza4Marcel Lyra Cunha5Gustavo H. Goldman6Anne Beauvais7Jean-Paul Latgé8Leila M. Lopes-Bezerra9Universidade do Estado do Rio de Janeiro, Campus Maracanã, Pavilhão Haroldo Lisboa da Cunha sl 501D, CEP: 20550-013, Rio de Janeiro, RJ, BrazilUniversidade do Estado do Rio de Janeiro, Campus Maracanã, Pavilhão Haroldo Lisboa da Cunha sl 501D, CEP: 20550-013, Rio de Janeiro, RJ, BrazilUniversidade do Estado do Rio de Janeiro, Campus Maracanã, Pavilhão Haroldo Lisboa da Cunha sl 501D, CEP: 20550-013, Rio de Janeiro, RJ, BrazilUnité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris Cedex 15, FranceMS Applications Research and Development Laboratory, Waters Corporation, São Paulo, BrazilUniversidade do Estado do Rio de Janeiro, Campus Maracanã, Pavilhão Haroldo Lisboa da Cunha sl 501D, CEP: 20550-013, Rio de Janeiro, RJ, BrazilUniversidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Ciências Farmacêuticas. Av. do Cafe S/N, Monte Alegre, CEP:14040-903, Ribeirao Preto, SP, BrazilUnité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris Cedex 15, FranceUnité des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris Cedex 15, FranceUniversidade do Estado do Rio de Janeiro, Campus Maracanã, Pavilhão Haroldo Lisboa da Cunha sl 501D, CEP: 20550-013, Rio de Janeiro, RJ, BrazilInvasive aspergillosis is the primary opportunistic invasive fungal infection described in neutropenic hematologic patients, caused by the angioinvasive pathogen Aspergillus fumigatus. The molecular mechanisms associated with A. fumigatus infection in the vascular endothelium are poorly understood. In this context, we used a high-throughput proteomic approach to unveil the proteins modulated in HUVECs after interaction with a wild type strain and the UGM1 mutant (Δugm1) of A. fumigatus. The proteomic analysis was also performed in HUVECs challenged with a galactosaminogalactan (GAG) purified from A. fumigatus cell wall. The dataset presented here correspond to all proteins identified that fit a 2-fold change criteria (log 2 ratio ≥ 1 or ≤ −1), disregarding the statistical validation cut off, in order to supplement the research article entitled “Modifications to the composition of the hyphal outer layer of Aspergillus fumigatus modulates the HUVEC proteins associated with inflammatory and stress responses” (G.W.P. Neves, N.A. Curty, P.H. Kubitschek-Barreira, T. Fontaine, G.H.M.F. Souza, M. Lyra Cunha, G.H. Goldman, A. Beauvais, J.P. Latgé, L.M. Lopes-Bezerra, 2016) [1]. The mass spectrometry proteomic data have been deposited in the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PRIDE: PXD002823.http://www.sciencedirect.com/science/article/pii/S235234091630498XAspergillus fumigatusHUVECGAGUGM1 mutantPROTEOMEInvasive aspergillosis |
| spellingShingle | Gabriela Westerlund Peixoto Neves Nathália Curty Paula Helena Kubitschek-Barreira Thierry Fontaine Gustavo Henrique Martins Ferreira Souza Marcel Lyra Cunha Gustavo H. Goldman Anne Beauvais Jean-Paul Latgé Leila M. Lopes-Bezerra Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strains Data in Brief Aspergillus fumigatus HUVEC GAG UGM1 mutant PROTEOME Invasive aspergillosis |
| title | Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strains |
| title_full | Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strains |
| title_fullStr | Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strains |
| title_full_unstemmed | Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strains |
| title_short | Dataset of differentially regulated proteins in HUVECs challenged with wild type and UGM1 mutant Aspergillus fumigatus strains |
| title_sort | dataset of differentially regulated proteins in huvecs challenged with wild type and ugm1 mutant aspergillus fumigatus strains |
| topic | Aspergillus fumigatus HUVEC GAG UGM1 mutant PROTEOME Invasive aspergillosis |
| url | http://www.sciencedirect.com/science/article/pii/S235234091630498X |
| work_keys_str_mv | AT gabrielawesterlundpeixotoneves datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT nathaliacurty datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT paulahelenakubitschekbarreira datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT thierryfontaine datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT gustavohenriquemartinsferreirasouza datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT marcellyracunha datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT gustavohgoldman datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT annebeauvais datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT jeanpaullatge datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains AT leilamlopesbezerra datasetofdifferentiallyregulatedproteinsinhuvecschallengedwithwildtypeandugm1mutantaspergillusfumigatusstrains |