Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study
Background Mohs micrographic surgery (MMS) is the preferable surgery for difficult -to-treat basal cell carcinoma (BCC) but is an expensive, labor-intensive, and time-consuming technique. The aim of this study is to compare the efficacy and safety of photodynamic therapy combined with surgery(S-PDT)...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2023.2200871 |
| _version_ | 1827816496881991680 |
|---|---|
| author | Nianzhou Yu Lisha Wu Juan Su Mingliang Chen Lixia Lu Kai Huang Yixin Li Zixi Jiang Siliang Liu Lanyuan Peng Yang Xie Zeyu Chen Wenhu Zhou Miaojian Wan Fang Fang WenBo Bu Shuang Zhao |
| author_facet | Nianzhou Yu Lisha Wu Juan Su Mingliang Chen Lixia Lu Kai Huang Yixin Li Zixi Jiang Siliang Liu Lanyuan Peng Yang Xie Zeyu Chen Wenhu Zhou Miaojian Wan Fang Fang WenBo Bu Shuang Zhao |
| author_sort | Nianzhou Yu |
| collection | DOAJ |
| description | Background Mohs micrographic surgery (MMS) is the preferable surgery for difficult -to-treat basal cell carcinoma (BCC) but is an expensive, labor-intensive, and time-consuming technique. The aim of this study is to compare the efficacy and safety of photodynamic therapy combined with surgery(S-PDT) versus Mohs micrographic surgery (MMS) for the treatment of difficult-to-treat BCC. Methods This was a retrospective, comparative study. A total of 32 patients, 16 patients with 48 lesions, were treated with S-PDT, and the other 16 patients with 17 lesions treated by MMS were enrolled in this study. Follow-up was at least 36 months posttreatment. Results The recurrence rate was no statistical difference between the S-PDT and MMS (p = 1.000, Fishers exact test). The median follow-up was 42.5 months (range 36–63 months). The mean healing time in the S-PDT [17.9 d (SD 9.8)] is longer than in MMS [7.5 d (SD 1.5)] during follow-up (p＜.001, Independent T-test). On the whole, the cosmetic outcome of patients in S-PDT was statistically no significant difference with that in MMS according to a 4-point scale (p = .719, chi-squared test). Conclusions S-PDT is a safe, effective, and novel cosmetic treatment, which holds the potential to be an alternative treatment to MMS for some cases. |
| first_indexed | 2024-03-12T00:15:10Z |
| format | Article |
| id | doaj.art-a80d5e5278b24b628fc10b10a5daeee2 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:10Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-a80d5e5278b24b628fc10b10a5daeee22023-09-15T14:28:53ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532023-12-0134110.1080/09546634.2023.22008712200871Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical studyNianzhou Yu0Lisha Wu1Juan Su2Mingliang Chen3Lixia Lu4Kai Huang5Yixin Li6Zixi Jiang7Siliang Liu8Lanyuan Peng9Yang Xie10Zeyu Chen11Wenhu Zhou12Miaojian Wan13Fang Fang14WenBo Bu15Shuang Zhao16Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityXiangya School of Medicine, Central South UniversityDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityDepartment of Dermatology, The 3rd Affiliated Hospital of Sun Yat‐Sen UniversityState Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South UniversityXiangya School of Pharmaceutical Sciences, Central South UniversityDepartment of Dermatology, The 3rd Affiliated Hospital of Sun Yat‐Sen UniversityState Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South UniversityDepartment of Dermatologic Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South UniversityBackground Mohs micrographic surgery (MMS) is the preferable surgery for difficult -to-treat basal cell carcinoma (BCC) but is an expensive, labor-intensive, and time-consuming technique. The aim of this study is to compare the efficacy and safety of photodynamic therapy combined with surgery(S-PDT) versus Mohs micrographic surgery (MMS) for the treatment of difficult-to-treat BCC. Methods This was a retrospective, comparative study. A total of 32 patients, 16 patients with 48 lesions, were treated with S-PDT, and the other 16 patients with 17 lesions treated by MMS were enrolled in this study. Follow-up was at least 36 months posttreatment. Results The recurrence rate was no statistical difference between the S-PDT and MMS (p = 1.000, Fishers exact test). The median follow-up was 42.5 months (range 36–63 months). The mean healing time in the S-PDT [17.9 d (SD 9.8)] is longer than in MMS [7.5 d (SD 1.5)] during follow-up (p＜.001, Independent T-test). On the whole, the cosmetic outcome of patients in S-PDT was statistically no significant difference with that in MMS according to a 4-point scale (p = .719, chi-squared test). Conclusions S-PDT is a safe, effective, and novel cosmetic treatment, which holds the potential to be an alternative treatment to MMS for some cases.http://dx.doi.org/10.1080/09546634.2023.2200871basal-cell carcinoma (bcc)photodynamic therapy (pdt)mohs micrographic surgery (mms)treatment outcome |
| spellingShingle | Nianzhou Yu Lisha Wu Juan Su Mingliang Chen Lixia Lu Kai Huang Yixin Li Zixi Jiang Siliang Liu Lanyuan Peng Yang Xie Zeyu Chen Wenhu Zhou Miaojian Wan Fang Fang WenBo Bu Shuang Zhao Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study Journal of Dermatological Treatment basal-cell carcinoma (bcc) photodynamic therapy (pdt) mohs micrographic surgery (mms) treatment outcome |
| title | Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study |
| title_full | Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study |
| title_fullStr | Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study |
| title_full_unstemmed | Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study |
| title_short | Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study |
| title_sort | photodynamic therapy combined with surgery versus mohs micrographic surgery for the treatment of difficult to treat basal cell carcinoma a retrospective clinical study |
| topic | basal-cell carcinoma (bcc) photodynamic therapy (pdt) mohs micrographic surgery (mms) treatment outcome |
| url | http://dx.doi.org/10.1080/09546634.2023.2200871 |
| work_keys_str_mv | AT nianzhouyu photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT lishawu photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT juansu photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT mingliangchen photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT lixialu photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT kaihuang photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT yixinli photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT zixijiang photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT siliangliu photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT lanyuanpeng photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT yangxie photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT zeyuchen photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT wenhuzhou photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT miaojianwan photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT fangfang photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT wenbobu photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy AT shuangzhao photodynamictherapycombinedwithsurgeryversusmohsmicrographicsurgeryforthetreatmentofdifficulttotreatbasalcellcarcinomaaretrospectiveclinicalstudy |