Cerebrovascular accidents in patients with type 2 diabetes mellitus
Cerebrovascular accident (CA) is a nowadays widely spread, highly incapacitating and often lethal event that poses a prominent clini- cal problem. Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) ? an ?epidemic? of the century, ? are known to be its primary risk factors. Hyperglycemi...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2013-03-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/3599 |
| _version_ | 1797255230417534976 |
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| author | Sergey Valentinovich Kakorin E V Tulyakova K V Voronkova Ashot Musaelovich Mkrtumyan |
| author_facet | Sergey Valentinovich Kakorin E V Tulyakova K V Voronkova Ashot Musaelovich Mkrtumyan |
| author_sort | Sergey Valentinovich Kakorin |
| collection | DOAJ |
| description | Cerebrovascular accident (CA) is a nowadays widely spread, highly incapacitating and often lethal event that poses a prominent clini- cal problem. Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) ? an ?epidemic? of the century, ? are known to be its primary risk factors. Hyperglycemia promotes CA risks by induction of protein glycosylation, elevation of blood plasma atherogenic potential, activation of coagulation system with higher risk for thrombosis and disturbance of microcirculation on tissue and organ lev- els. Influence of hyperglycemia on severity and extent of neurologic damage is still under evaluation. Development of macroangiopathy is thought to be associated with media calcification, distal polyneuropathy and renal disorders, all of which are cardiovascular risk factors. Application of so-called metabolic drugs resulted in certain disillusionment, as these agents failed to prove their efficacy during clinical trials. Incidence of pulmonary edema in patients with ischemic CA and T2DM is important as it dictates the necessity for use of loop diuretics. Incidence and severity of heart failure and its correlation with degree of glycemic disorders, incidence of pulmonary em- bolism, as well as tactics of management and prognosis in patients with ischemic CA and T2DM, remains a relevant research problem. |
| first_indexed | 2024-03-08T15:21:36Z |
| format | Article |
| id | doaj.art-a80fd28e9a6e45ac8d20946f5175c66c |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:33Z |
| publishDate | 2013-03-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-a80fd28e9a6e45ac8d20946f5175c66c2024-03-20T11:47:58ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-03-01161637010.14341/2072-0351-35993569Cerebrovascular accidents in patients with type 2 diabetes mellitusSergey Valentinovich Kakorin0E V Tulyakova1K V Voronkova2Ashot Musaelovich Mkrtumyan3Moscow City Hospital №63, MoscowMoscow City Hospital №63, MoscowRussian National Research Medical University, Moscow3 Moscow State University of Medicine and Dentistry, MoscowCerebrovascular accident (CA) is a nowadays widely spread, highly incapacitating and often lethal event that poses a prominent clini- cal problem. Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) ? an ?epidemic? of the century, ? are known to be its primary risk factors. Hyperglycemia promotes CA risks by induction of protein glycosylation, elevation of blood plasma atherogenic potential, activation of coagulation system with higher risk for thrombosis and disturbance of microcirculation on tissue and organ lev- els. Influence of hyperglycemia on severity and extent of neurologic damage is still under evaluation. Development of macroangiopathy is thought to be associated with media calcification, distal polyneuropathy and renal disorders, all of which are cardiovascular risk factors. Application of so-called metabolic drugs resulted in certain disillusionment, as these agents failed to prove their efficacy during clinical trials. Incidence of pulmonary edema in patients with ischemic CA and T2DM is important as it dictates the necessity for use of loop diuretics. Incidence and severity of heart failure and its correlation with degree of glycemic disorders, incidence of pulmonary em- bolism, as well as tactics of management and prognosis in patients with ischemic CA and T2DM, remains a relevant research problem.https://www.dia-endojournals.ru/jour/article/view/3599cerebrovascular accidentcardiovascular diseasetype 2 diabetes mellitusmacroangiopathymonckeberg's arteriosclerosisheart failureindirect anticoagulantsneuroprotectors |
| spellingShingle | Sergey Valentinovich Kakorin E V Tulyakova K V Voronkova Ashot Musaelovich Mkrtumyan Cerebrovascular accidents in patients with type 2 diabetes mellitus Сахарный диабет cerebrovascular accident cardiovascular disease type 2 diabetes mellitus macroangiopathy monckeberg's arteriosclerosis heart failure indirect anticoagulants neuroprotectors |
| title | Cerebrovascular accidents in patients with type 2 diabetes mellitus |
| title_full | Cerebrovascular accidents in patients with type 2 diabetes mellitus |
| title_fullStr | Cerebrovascular accidents in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Cerebrovascular accidents in patients with type 2 diabetes mellitus |
| title_short | Cerebrovascular accidents in patients with type 2 diabetes mellitus |
| title_sort | cerebrovascular accidents in patients with type 2 diabetes mellitus |
| topic | cerebrovascular accident cardiovascular disease type 2 diabetes mellitus macroangiopathy monckeberg's arteriosclerosis heart failure indirect anticoagulants neuroprotectors |
| url | https://www.dia-endojournals.ru/jour/article/view/3599 |
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