Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot Study
Introduction: Anal fissure (AF) is a common anorectal disease. Although several pharmacological treatments are available, many patients still require surgical interventions. In this study, we aimed to evaluate the efficacy of an ointment based on a multifunctional blend of herbal ingredients includi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-02-01
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| Series: | Medical Cannabis and Cannabinoids |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/528119 |
| _version_ | 1811161443284811776 |
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| author | Edward Ram Yaniv Zager Raanan Meyer Dan Carter Samia Joubran Nir Horesh |
| author_facet | Edward Ram Yaniv Zager Raanan Meyer Dan Carter Samia Joubran Nir Horesh |
| author_sort | Edward Ram |
| collection | DOAJ |
| description | Introduction: Anal fissure (AF) is a common anorectal disease. Although several pharmacological treatments are available, many patients still require surgical interventions. In this study, we aimed to evaluate the efficacy of an ointment based on a multifunctional blend of herbal ingredients including hemp (ProctoFiz) for chronic AF. Methods: A single-arm, questionnaire-based prospective study was conducted in a large tertiary center to evaluate the outcomes of patients suffering from chronic AF treated with topical ProctoFiz. Results: Ninety-two patients were included in the study, 54 (58.7%) were females with a median age of 39 (range 17–78). 32 patients (34.7%) suffered from recurrent AF before enrolling in the study, and 5 patients (5.4%) underwent previous surgical interventions for AF. Three patients (3.2%) were lost to follow-up, leaving 89 patients for analysis. Eighty patients (89.9%) reported significant improvement of symptoms after 1 week using ProctoFiz, and 79 patients reported continued improvement after 1 month of treatment. The mean pain Visual Analog Score (VAS) declined by 6.6 points (8.9 vs. 2.3; 95% CI: 7.20 to −5.99, p < 0.0001) following 1 week of treatment, with continuous improvement to a mean of 0.64 after 1 month. Negative impact on quality of life significantly decreased from a mean of 8.8 to 0.38 following a month of treatment (p < 0.0001), with significant reduction in the number of patients suffering from bleeding following bowel movements (64.1–2.5%; p = 0.0001). Conclusion: Hemp-based topical treatment of AF is feasible and significantly improves AF-correlated symptoms. |
| first_indexed | 2024-04-10T06:15:24Z |
| format | Article |
| id | doaj.art-a8127072f2774075bf3d99c80ef68f6a |
| institution | Directory Open Access Journal |
| issn | 2504-3889 |
| language | English |
| last_indexed | 2024-04-10T06:15:24Z |
| publishDate | 2023-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Medical Cannabis and Cannabinoids |
| spelling | doaj.art-a8127072f2774075bf3d99c80ef68f6a2023-03-02T10:03:56ZengKarger PublishersMedical Cannabis and Cannabinoids2504-38892023-02-0161152010.1159/000528119528119Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot StudyEdward Ram0Yaniv Zager1Raanan Meyer2Dan Carter3Samia Joubran4Nir Horesh5https://orcid.org/0000-0002-2459-8567Department of General Surgery and Transplantations, Sheba Medical Center, Ramat Gan, IsraelDepartment of General Surgery and Transplantations, Sheba Medical Center, Ramat Gan, IsraelFaculty of Medicine, Tel Aviv University, Tel Aviv, IsraelFaculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of General Surgery and Transplantations, Sheba Medical Center, Ramat Gan, IsraelDepartment of General Surgery and Transplantations, Sheba Medical Center, Ramat Gan, IsraelIntroduction: Anal fissure (AF) is a common anorectal disease. Although several pharmacological treatments are available, many patients still require surgical interventions. In this study, we aimed to evaluate the efficacy of an ointment based on a multifunctional blend of herbal ingredients including hemp (ProctoFiz) for chronic AF. Methods: A single-arm, questionnaire-based prospective study was conducted in a large tertiary center to evaluate the outcomes of patients suffering from chronic AF treated with topical ProctoFiz. Results: Ninety-two patients were included in the study, 54 (58.7%) were females with a median age of 39 (range 17–78). 32 patients (34.7%) suffered from recurrent AF before enrolling in the study, and 5 patients (5.4%) underwent previous surgical interventions for AF. Three patients (3.2%) were lost to follow-up, leaving 89 patients for analysis. Eighty patients (89.9%) reported significant improvement of symptoms after 1 week using ProctoFiz, and 79 patients reported continued improvement after 1 month of treatment. The mean pain Visual Analog Score (VAS) declined by 6.6 points (8.9 vs. 2.3; 95% CI: 7.20 to −5.99, p < 0.0001) following 1 week of treatment, with continuous improvement to a mean of 0.64 after 1 month. Negative impact on quality of life significantly decreased from a mean of 8.8 to 0.38 following a month of treatment (p < 0.0001), with significant reduction in the number of patients suffering from bleeding following bowel movements (64.1–2.5%; p = 0.0001). Conclusion: Hemp-based topical treatment of AF is feasible and significantly improves AF-correlated symptoms.https://www.karger.com/Article/FullText/528119anal fissurecannabinoid treatmentsurgeryclinical trialanalgesia |
| spellingShingle | Edward Ram Yaniv Zager Raanan Meyer Dan Carter Samia Joubran Nir Horesh Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot Study Medical Cannabis and Cannabinoids anal fissure cannabinoid treatment surgery clinical trial analgesia |
| title | Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot Study |
| title_full | Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot Study |
| title_fullStr | Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot Study |
| title_full_unstemmed | Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot Study |
| title_short | Management of Chronic Anal Fissure with a Novel Topical Hemp-Herbal-Based Ointment: A Pilot Study |
| title_sort | management of chronic anal fissure with a novel topical hemp herbal based ointment a pilot study |
| topic | anal fissure cannabinoid treatment surgery clinical trial analgesia |
| url | https://www.karger.com/Article/FullText/528119 |
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