Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection

Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection

Abstract Background Lower respiratory infections are a leading cause of severe morbidity and mortality among older adults. Despite ubiquitous exposure to common respiratory pathogens throughout life and near universal seropositivity, antibodies fail to effectively protect the elderly. Therefore, we...

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Bibliographic Details
Main Authors: Olivia B. Parks, Taylor Eddens, Jorna Sojati, Jie Lan, Yu Zhang, Tim D. Oury, Manda Ramsey, John J. Erickson, Craig A. Byersdorfer, John V. Williams
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Immunity & Ageing
Subjects:
Respiratory viral infection
Aged immune response
Viral immunology
Online Access:https://doi.org/10.1186/s12979-023-00365-5

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